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:: دوره 7، شماره 3 - ( 6-1392 ) ::
جلد 7 شماره 3 صفحات 22-26 برگشت به فهرست نسخه ها
Adenovector Mediated Inflammation in Mice Liver Boosted by Hydrodynamic Injection
چکیده:   (1873 مشاهده)
Background and Aims: Adenovector gene transfer induces inflammatory response that finally leads to vector removal from delivered site. The effect of hydrodynamic pre-injection on Adenovector mediated liver inflammation remained elusive. Materials and Methods: Different mice groups were pre-treated by hydrodynamic saline, dexamethasone or nothing prior to Adeno-Luciferase administration. Their samples were collected in 18 hours later and serum IL-1β level as a marker of inflammation was quantified. Also, liver histological assessment was performed to score the inflammatory grade. Results and Conclusion: In spite of dexamethasone group, both hydrodynamic/Ad-Luc and Ad-Luc receiving groups induced the expression of IL-1β cytokine (p<0.05). The pathological views also indicated more inflammation and necrosis inside the different zones of liver tissue in these two adenovector injected groups. These results emphasized that Adenovector served as a suitable inflammatory model and hydrodynamic injection enhances this kind of inflammation.
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نوع مطالعه: پژوهشي | موضوع مقاله: عمومى
دریافت: ۱۳۹۴/۳/۱ | پذیرش: ۱۳۹۴/۳/۱ | انتشار: ۱۳۹۴/۳/۱
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Rezaei F, Hosseini S Y, Pakniat A, Geramizadeh B, Fattahi M, Nejabat N et al . Adenovector Mediated Inflammation in Mice Liver Boosted by Hydrodynamic Injection. Iran J Virol. 2013; 7 (3) :22-26
URL: http://journal.isv.org.ir/article-1-133-fa.html

Adenovector Mediated Inflammation in Mice Liver Boosted by Hydrodynamic Injection. مجله ویروس شناسی ایران. 1392; 7 (3) :22-26

URL: http://journal.isv.org.ir/article-1-133-fa.html



دوره 7، شماره 3 - ( 6-1392 ) برگشت به فهرست نسخه ها
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