[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Medical Journalism::
::
Search in website

Advanced Search
..
INDEX









 
..
:: Volume 10, Issue 2 And 3 (9-2016) ::
Iran J Virol 2016, 10(2 And 3): 19-24 Back to browse issues page
Distribution of Hepatitis C virus genotypes in Yazd, Central Province of Iran: increasing the mixed genotypes
Nastaran Ansari , Masoud Doosti , Abbas Ahmadi , Ehsan Kakavandi , Shaghayegh Yazdani , Mohammad Shayestehpour *
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract:   (4516 Views)
Background and Aims: Different hepatitis C virus (HCV) genotypes have characteristic geographical distribution. Identification of HCV genotype is an important factor in the progression, clinical outcome and therapy of HCV infection. The aim of this study was to determine the prevalence of HCV genotypes among HCV-RNA positive patients in Yazd, Iran.
Materials and Methods: In this cross-sectional study, 150 HCV-infected individuals with detectable plasma HCV RNA levels were enrolled from January to August 2015. HCV-RNA was extracted from plasma samples and retro-transcribed to c-DNA. Then HCV genotypes 1, 2, 3a, 4 were determined using a PCR based genotyping kit.
Results: A total of 150 HCV-positive patients with mean age 40.45±11.83 were enrolled in the study. 89.3% of participant were males and 10.7% were females. The most common genotype was 3a (52%), followed by 1a (28%).  Mixed-genotype infection was 20% and the most prevalent mixed genotype was 3a/1a (83% of mixed genotypes). The other genotypes were 1a/1b/3a in 10%, 3a/2 and 1a/2/3a both in 3% of patients with mixed HCV genotypes.
Conclusions: Unlike other regions of Iran, Genotypes 3a was predominant in HCV-RNA positive patients in Yazd province. Also, HCV mixed-genotype infections are more common than previously estimated in other studies from different parts of the country.
Keywords: Genotype, Hepatitis C virus, Iran
Full-Text [PDF 351 kb]   (988 Downloads)    
Type of Study: Original article | Subject: General
Received: 2017/05/14 | Accepted: 2017/07/29 | Published: 2017/07/29
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ansari N, Doosti M, Ahmadi A, Kakavandi E, Yazdani S, Shayestehpour M. Distribution of Hepatitis C virus genotypes in Yazd, Central Province of Iran: increasing the mixed genotypes. Iran J Virol 2016; 10 (2 and 3) :19-24
URL: http://journal.isv.org.ir/article-1-275-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 10, Issue 2 And 3 (9-2016) Back to browse issues page
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4645