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:: دوره 11، شماره 3 - ( 6-1396 ) ::
جلد 11 شماره 3 صفحات 18-13 برگشت به فهرست نسخه ها
Investigation of the Relationship between HTLV-1 Infection and MMP-3 Gene Expression in HTLV-1 Positive Cardiac Patients
چکیده:   (2258 مشاهده)
Background and Aims: Human T-lymphotropic virus type 1 (HTLV-1) is a member of retroviridae family that causes ATL and HAM/TSP. Many inflammatory diseases are associated with this virus, such as Sjögren's syndrome, Hashimoto's thyroiditis, Uveitis and also Atherosclerosis. HTLV-1 performs in long latency period and can activate the immune responses in coronary vessels. Activated immune system produces inflammatory factors such as TNF-α cytokine that can increase Matrix Metalloproteinases as a main factor in patients with coronary artery diseases (CAD). We aimed to determine the relation between this virus infection and MMP-3 expression in Atherosclerosis patients.
Materials and Methods: 44 patients (13 individuals CAD+ HTLV-1+, 8 individuals CAD- HTLV-1+, 13 individuals CAD+ HTLV-1-      and 10 individuals CAD- HTLV-1-) were selected and MMP-3 gene expression was measured by Real-time polymerase chain reaction. Results: There was no significant correlation between MMP-3 gene expression and HTLV-1 expression level in HTLV-1-positive cardiac and Atherosclerosis patients.
Conclusions: Although the main risk factor in Atherosclerosis patients is MMP-3, despite our expectation, no significant correlation was observed in our statistical analysis within four examined groups (p≥0.05). This evaluation showed higher MMP-3gene expression but not significant in CAD+ HTLV-1+ group compared to CAD+ HTLV-1- group. The larger sample sizes may help to improve the outcome to reach a significant level.
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نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: 1397/3/24 | پذیرش: 1397/6/16 | انتشار: 1397/6/16
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Mohammadhosayni M, Hajighasemi F, Rezaee A, Mozayani F, Mohammadi F S, Tarban N, et al . Investigation of the Relationship between HTLV-1 Infection and MMP-3 Gene Expression in HTLV-1 Positive Cardiac Patients. Iran J Virol. 2017; 11 (3) :13-18
URL: http://journal.isv.org.ir/article-1-327-fa.html

Investigation of the Relationship between HTLV-1 Infection and MMP-3 Gene Expression in HTLV-1 Positive Cardiac Patients. مجله ویروس شناسی ایران. 1396; 11 (3) :18-13

URL: http://journal.isv.org.ir/article-1-327-fa.html



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دوره 11، شماره 3 - ( 6-1396 ) برگشت به فهرست نسخه ها
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