[صفحه اصلی ]   [Archive]  
:: صفحه اصلي :: درباره نشريه :: آخرين شماره :: تمام شماره‌ها :: جستجو :: ثبت نام :: ارسال مقاله :: تماس با ما ::
:: دوره 6، شماره 1 - ( 11-1390 ) ::
جلد 6 شماره 1 صفحات 18-26 برگشت به فهرست نسخه ها
Phylogenetic Analysis of Hemagglutinin Gene of H9N2 Avian Influenza Viruses Isolated from Chicken in Iran in 2010-2011: Emerging of a New Subgroup
چکیده:   (4861 مشاهده)
Background and Aims: Hemagglutinin (HA) protein of Avian Influenza (AI) plays an essential role in the virus pathogenicity. AI H9N2 subtype causes significant economic loss in broiler and layer in poultry farms in Iran. AI viruses have a great involvement in evolutionary changes at nucleotide and amino acid levels and vaccines could induce faster rates of such changes. Up-dated understanding of the genetic changes of AI viruses circulating in Iran is necessary for controlling AI. Materials and Methods: Sequence analysis and phylogenetic study of the HA gene of three H9N2 subtype of AI isolates in Iran in 2010-2011 were studied. Results: Cleavage site of the Iranian 2010-2011 isolates possessed a different motif. Amino acid residue at position 226 at receptor binding site in these isolates was Leucine, which was similar to human viruses. The epitopes for HA showed a great variation related to the year of isolation. According to phylogenetic analysis, Iranian isolates were divided into two main subgroups. But, viruses isolated in this study formed a third minor subgroup. Degree of homology between the 2010-2011 isolates and former Iranian isolates was significantly low. Conclusion: The results revealed that HA of new Iranian AI H9N2 isolates have undergone extensive genetic changes. Definitely, continuous monitoring of genetic changes is a useful tool for updating control strategy for AI outbreak in Iran.
متن کامل [PDF 397 kb]   (1102 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: عمومى
دریافت: 1393/8/16 | پذیرش: 1393/8/16 | انتشار: 1393/8/16
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA



XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Norouzian H, Gholami S, Vasfi-Marandi M. Phylogenetic Analysis of Hemagglutinin Gene of H9N2 Avian Influenza Viruses Isolated from Chicken in Iran in 2010-2011: Emerging of a New Subgroup. Iran J Virol. 2012; 6 (1) :18-26
URL: http://journal.isv.org.ir/article-1-86-fa.html

Phylogenetic Analysis of Hemagglutinin Gene of H9N2 Avian Influenza Viruses Isolated from Chicken in Iran in 2010-2011: Emerging of a New Subgroup. مجله ویروس شناسی ایران. 1390; 6 (1) :18-26

URL: http://journal.isv.org.ir/article-1-86-fa.html



بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.
دوره 6، شماره 1 - ( 11-1390 ) برگشت به فهرست نسخه ها
Persian site map - English site map - Created in 0.04 seconds with 30 queries by YEKTAWEB 4331