%0 Journal Article %A Pourrezaei, S %A jafarpour, A %A Aghamiri, Sh %A Molai, Hamid Reza %A Arabzadeh, Ali Mohammad %A Shahani, T %T Evaluation of Epstein - Barr virus Frequency in Paraffin-Embedded Tissues of Hodgkin and Non-Hodgkin Lymphoma Patients in Kerman Province %J Iranian Journal of Virology %V 11 %N 4 %U http://journal.isv.org.ir/article-1-331-en.html %R %D 2017 %K Hodgkin's lymphoma, Non-Hodgkin`s lymphoma, Epstein-Barr Virus, Real -Time-PCR, %X Background and Aims: EBV infection usually occurs in humans and is very common. Sero-epidemiological surveys show that over 95% of adults worldwide are faced with EBV virus. The Epstein-Barr virus causes infectious mononucleosis and its association with a number of human cancers, including Hodgkin's lymphoma, non-Hodgkin lymphoma (especially lymphoma BL), nasopharyngeal carcinoma, gastric carcinoma and breast cancer has been established. Materials and Methods: This study was conducted cross-sectional. This study was designed to determine the presence of the Epstein-Barr virus genome in tissue samples of patients with Hodgkin lymphoma and non-Hodgkins. In this study, 40 samples of patients with non-Hodgkin's lymphoma and Hodgkin's disease, while had been kept in archives of the Shahid Bahonar Hospital, Afzalipour Hospital and Payambar-e-Azam Hospital of Kerman were examined by real-time PCR technique. The data collected by SPSS software and chi-square test were analyzed. Results: The prevalence of EBV in patients in this study was 5/27% of the 40 sample, of which 20 cases were of Hodgkin lymphoma and 20 cases were of non-Hodgkin lymphoma. No significant correlation was found between the prevalence of EBV in Hodgkin and non-Hodgkin lymphoma. There was also no correlation between men and women of different ages for the presence of EBV DNA in patients samples (P>0.05). Conclusions: EBV DNA associated with the tumor could be detected by molecular methods which are useful for the diagnosis of EBV-associated diseases, also biological factors such as age, sex, health status, social and economic factors in the pathogenesis of EBV and its relationship to lymphoma was not observed. %> http://journal.isv.org.ir/article-1-331-en.pdf %P 1-7 %& 1 %! %9 Original article %L A-10-157-1 %+ Virology Department, School of Medicine, Kerman University of Medical Sciences, Kerman, IR Iran %G eng %@ 1735-5680 %[ 2017