TY - JOUR JF - virusj JO - Iran J Virol VL - 1 IS - 4 PY - 2007 Y1 - 2007/11/01 TI - Peganum harmala seed extract can prevent HSV-1 replication in vitro TT - N2 - Abstract: Peganum harmala L. (Zygophylaceae) has been used in a variety of practical applications in medical science. Our objective in the current study was to determine the effects of the seed extract on Herpes simplex virus type 1 (HSV-1) replication in Vero cells. Different concentrations (100, 500, 571, 667, 800 and 1000 µg/ml) of the extract were examined. Experiments were carried out using Vero cells. P.harmala seed extract was found to be non-toxic to Vero cells up to a concentration of 667 µg/ml. The antiviral activity of non-toxic concentration against HSV-1 was tested. The replication of HSV-1 was inhibited, indicating that the P.harmala L. extract contains an anti-HSV-1 substance. SP - 11 EP - 16 AU - Kiani, S.J AU - Shamsi Shahrabadi, M AU - Ataei, A AU - Sajjadi, N AD - Department of Virology, Iran University of Medical Sciences, Tehran, IRAN KW - Peganum harmala L. KW - Vero cells KW - TCID50 KW - Cytotoxicity UR - http://journal.isv.org.ir/article-1-211-en.html DO - 10.21859/isv.1.4.11 ER -