Iranian Journal of Virology
مجله ویروس شناسی ایران
Iran J Virol
Medical Sciences
http://journal.isv.org.ir
1
admin
1735-5680
2588-5030
10.21859/isv
en
jalali
1393
8
1
gregorian
2014
11
1
8
2
online
1
fulltext
en
Comparison of clinico - pathological changes in SPF chickens infected with different Iranian genotypes of infectious bronchitis virus
تخصصي
Special
پژوهشي
Original article
<p>Introduction: Infectious bronchitis (IB), caused by infectious bronchitis virus (IBV), is an acute and highly contagious disease in chickens. IBV is mainly considered a respiratory infection, other clinical manifestations, including renal, enteric and reproductive signs can be observed. Aim: Since there has been no study on evaluation of changes in biochemical parameters during IB infection, this study designed to assess the serum biochemical factors in experimentally infected chicks with two IBV isolates. Methods: Two groups of 14-day-old SPF chickens were infected with two different isolates of IBV, Variant-2 like and IR-1 like genotypes respectively (35 chicks in each group). In addition, a group of 35 chickens remained non-infected as a control group. On days 1, 3, 5, 7, 14 and 21 and 28 post infection the sera of both infected groups and un-inoculated control group was collected to measure the biochemical factors, including uric acid, creatinine, alanine amino transferase (ALT) and aspartate amino transferase (AST) using a standard auto analyzer. We used multiple comparison ANOVA followed by a post-hoc test, (Level of significance <0.05). Results: There were no significant differences between evaluated parameters of each infected group in comparison with the control group. Conclusion: No changes were seen in serum factor levels between control and infected groups. In an experimental disease, there was no other infection to superimpose on IBV, so acute IBV infection was not strong enough to cause hepatic dysfunction or renal failure.</p>
ClinicoPathological changes, Chickens, Infectious bronchitis virus
49
54
http://journal.isv.org.ir/browse.php?a_code=A-10-60-1&slc_lang=en&sid=1
Hamide
Najafi
10031947532846003314
10031947532846003314
No
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Arash
Ghalyanchi-Langeroudi
10031947532846003315
10031947532846003315
No
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Masoud
Hashemzadeh
10031947532846003316
10031947532846003316
Yes
Department of Research and Production of Poultry Viral Vaccine, Razi Vaccine and Serum Research Institute, Karaj, Iran
Omid
Madadgar
10031947532846003317
10031947532846003317
No
Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Vahid
Karimi
10031947532846003318
10031947532846003318
No
Department of Research and Production of Poultry Viral Vaccine, Razi Vaccine and Serum Research Institute, Karaj, Iran
Reza
Khaltabadi-Farahani
10031947532846003319
10031947532846003319
No
Department of Clinical sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Hossein
Maghsoudlo
10031947532846003320
10031947532846003320
No
Iranian veterinary organization, Tehran, Iran