en عمومى General پژوهشي Original article <div> <p><strong>Abstract</strong></p> <p><strong>Background and Aims:</strong> IP-10 molecule is a new biomarker to predict response to treatment in chronic HCV infection. Also urine IP-10 has been suggested as a biomarker in other infections. But already, it has low data in urine as well as serum level of IP-10 for HCV infection. The aim of this study was to assess urine and serum level of IP-10 in patients with type 1 and 3a HCV infection.</p> <p><strong>Materials and Methods:</strong> In this case-control study, 105 patients with HCV infection were involved in three 35 people groups. Blood and urine sample of all patients was collected to determine IP-10 level. Finally, data analysis was reported using SPSS, mean statistics analysis and T test.</p> <p><strong>Results:</strong> The age mean was 41.6&plusmn;11.2 ranging 21-68. Urine and serum level of IP-10 in patient group was significantly higher than control (p=0.001). Serum level of IP-10 based on HCV genotype was higher significantly in genotype 1a than 3a (p=0.001) but there was no significant difference of urine IP-10 level between genotypes 1a and 3a.</p> <p><strong>Conclusions: </strong>The results show IP-10 is a proper marker to determine the prognosis of fibrosis and progress liver inflammation and on the other hand, the prediction of response to treatment differs in various genotypes of HCV infection.</p> </div> Hepatitis C, IP-10, serum and urine, genotype 3a and 1a 1 8 http://journal.isv.org.ir/browse.php?a_code=A-10-78-3&slc_lang=en&sid=1 Zahra Moallemi ahvasmehjani@gmail.com 10031947532846003135 10031947532846003135 No Associate Professor, Infectious and Tropical Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Jamshid Ayatollahi a.ahmadi.tums.ac@gmail.com 10031947532846003136 10031947532846003136 Yes Associate Professor, Infectious and Tropical Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Masoud Doosti m.doosti58@gmail.com 10031947532846003137 10031947532846003137 No Associate Professor, Infectious and Tropical Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran