en عمومى General پژوهشي Original article <div style="border-style: solid none border-top-color: windowtext border-top-width: 1pt border-bottom-color: windowtext border-bottom-width: 1pt padding: 1pt 0in"> <p class="MsoNormal" style="direction: ltr unicode-bidi: embed border: none padding: 0in"><b>Background and Aims:</b> The safe, potent and effective live vaccines against Measles, Mumps and Rubella as important childhood diseases have been available for several decades. Several factors can affect the thermal stability of lyophilized vaccine. <!--stripped--><!--stripped--></p> <p class="MsoNormal" style="direction: ltr unicode-bidi: embed border: none padding: 0in"><b>Methods:</b> In this study, the effect of residual moisture on thermal stability of 61 batches of MMR vaccine was investigated using an accelerated method that has been recommended by World Health Organization (WHO). <!--stripped--><!--stripped--></p> <p class="MsoNormal" style="direction: ltr unicode-bidi: embed border: none padding: 0in"><b>Results:</b> Our results suggest that the best thermal stability for the lyophilized MMR vaccine is in a range of 1.51 to 2.00% of residual moisture with the minimum decrease in the all three components of the vaccines.<!--stripped--><!--stripped--></p> <p class="MsoNormal" style="direction: ltr unicode-bidi: embed border: none padding: 0in"><b>Conclusion: </b>It is suggested that<b>&nbsp;</b>the lyophilizators of MMR vaccine production lines should be programmed in a manner that the best range of residual moisture achieves.<b><!--stripped--><!--stripped--></b></p> </div> Thermostability, MMR vaccine, Residual moisture 25 28 http://journal.isv.org.ir/browse.php?a_code=A-10-1-5&slc_lang=en&sid=1 MK Shahkarami 10031947532846002509 10031947532846002509 Yes Human Viral Vaccines Department, Razi Vaccine & Serum Research Institute, Iran M Taqavian 10031947532846002510 10031947532846002510 No Human Viral Vaccines Department, Razi Vaccine & Serum Research Institute, Iran A Shafyi 10031947532846002511 10031947532846002511 No Human Viral Vaccines Department, Razi Vaccine & Serum Research Institute, Iran B Alirezaie 10031947532846002512 10031947532846002512 No Human Viral Vaccines Department, Razi Vaccine & Serum Research Institute, Iran F Esna-ashari 10031947532846002513 10031947532846002513 No Human Viral Vaccines Department, Razi Vaccine & Serum Research Institute, Iran S Soleimani 10031947532846002514 10031947532846002514 No Quality Control Department, Razi Vaccine & Serum Research Institute, Iran R Shahbazi 10031947532846002515 10031947532846002515 No Human Viral Vaccines Department, Razi Vaccine & Serum Research Institute, Iran