en عمومى General پژوهشي Original article <div><strong>Background and Aims:</strong> Hepatitis E virus is a public health concern and about a third of people in the world live in endemic areas. Although HEV is believed to be transmitted by fecal-oral routes between humans in low sanitary conditions, but evidence of transmission have been reported in hemodialysis (HD) patients.<br> <strong>Materials and Methods:</strong> Aim of present study was to determine the prevalence of anti-HEV antibody among HD patients in Gorgan, north of Iran. In this cross-sectional study, totally 300 HD patients from May to December 2014 were tested for detection of anti-HEV IgG and IgM by commercial HEV enzyme-linked immunosorbent assay (ELISA) kit. Demographic variables were collected in pre-designed questionnaires.<br> <strong>Results:</strong> Out of 300 individuals, 148 (49.3%) were male and 152 (50.7%) were female. The overall anti-HEV IgG seroprevalence rate was 4%. Result showed significant association between anti-HEV IgG and duration of dialysis (p = 0.03), but there were no significant differences between the subjects grouped according to gender, Ethnicity, dialysis per week and age. No anti-HEV IgM were detected in patients.<br> <strong>Conclusions: </strong>Since our finding showed statically significant relationship between duration of hemodialysis and anti-HEV. Therefore, hemodialysis maybe be considered as a risk factor in HEV transmission. However further studies are needed to confirm our data.</div> HEV, Hemodialysis, Seroprevalence, Iran 13 18 http://journal.isv.org.ir/browse.php?a_code=A-10-115-1&slc_lang=en&sid=1 Hamed Naziri Hamed.naziri65@gmail.com 10031947532846002986 10031947532846002986 No 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Alireza Tahamtan alireza.tmn@gmail.com 10031947532846002987 10031947532846002987 No 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Abdolvahab Moradi abmoradi@yahoo.com 10031947532846002988 10031947532846002988 No 2. Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran Alijan Tabarraei alijant@yahoo.com 10031947532846002989 10031947532846002989 Yes 2. Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran