Iranian Journal of Virology
مجله ویروس شناسی ایران
Iran J Virol
Medical Sciences
http://journal.isv.org.ir
1
admin
1735-5680
2588-5030
10.21859/isv
en
jalali
1395
6
1
gregorian
2016
9
1
10
2
online
1
fulltext
en
The comparative analysis of the protease molecule structure of the Human lymphotropic virus type-1 (HTLV-1)
عمومى
General
پژوهشي
Original article
<div><strong>Background and Aims:</strong> Human lymphotropic virus type-1 (HTLV-1) causes various diseases such as adult T-cell leukemia/lymphoma (ATLL) and HTLV-1 associated myelopathy/tropical spastic paraperesis (HAM / TSP) in humans. The main goal of this study is to compare Iranian protease subtypes structure of this virus (HTLV-1) to samples collected from other part of world in order to understand their differences.<br>
<strong>Materials and Methods:</strong> During 1394 -1395, 10 blood samples taken from HTLV-1 virus infected individuals. Samples went through polymerase chain reaction (PCR) process.The obtained products were sequenced and phylogenetic analysis were done. The second and third structures of these sequences were obtained by using a specialized websites.<br>
<strong>Results:</strong> The Iranian samples were completely exposed in to the cluster of Cosmopolitan subtype. The result of first structure alignment of protease protein in different subtypes of the virus, suggested some differences in the gene of interest. The conversion of the first structure to second and third structures and respectively pairwise and multiple alignment showed no significant difference in the protease protein conformation.<br>
<strong>Conclusions: </strong>The comparison of HTLV-1 virus protease protein from Iran and other sequences in the world which were obtained from GenBank shows no significant dissimilarity. This dissimilarity help to design the production of the drug. Therefore, future studies can be targeting a part of the protein and generalize the treatment outcomes to all subtypes circulating. This comparison have beneficiary effect in making the right medication that inhibit the subtypes of the virus in treatment studies of disease developed by this virus.</div>
Human lymphotropic virus type -1 (HTLV-1), protease, homology modeling
31
39
http://journal.isv.org.ir/browse.php?a_code=A-10-123-1&slc_lang=en&sid=1
Nastaran
tarban
nastarantarban88@gmail.com
10031947532846003000
10031947532846003000
No
Department of Biology, Kish International Campus, University of Tehran, Kish, Iran
Mehran
Habibi Rezaei
mhabibi@ut.ac.ir
10031947532846003001
10031947532846003001
No
School of Biology, College of Science, University of Tehran, Tehran, Iran
Mina
Shafifar
melika_shafi@yahoo.com
10031947532846003002
10031947532846003002
No
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Mina
Mohammad hosayni
nastarantarban88@gmail.com
10031947532846003003
10031947532846003003
No
Department of immunology, shahed university, school of medicine, Tehran, Iran
SeyedAbdolrahim
Rezaee
rezaeer@mums.ac.ir
10031947532846003004
10031947532846003004
No
Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Seyed Mohammad
Jazayeri
jazayeri42@gmail.com
10031947532846003005
10031947532846003005
No
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Mehdi
Norouzi
mnorouzi@tums.ac.ir
10031947532846003006
10031947532846003006
Yes
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran