Iranian Journal of Virology
مجله ویروس شناسی ایران
Iran J Virol
Medical Sciences
http://journal.isv.org.ir
1
admin
1735-5680
2588-5030
10.21859/isv
en
jalali
1396
6
1
gregorian
2017
9
1
11
3
online
1
fulltext
en
Challenges and Perspectives towards the Development of more Effective Influenza Vaccine
عمومى
General
مروری
Review article
<div>Influenza viruses continue to be a major health threat in human and bird populations. The improvements in formulation and production level of the current influenza vaccines are not sufficient to afford complete protection. The continuous antigenic drifts and emergence of endemic and zoonotic strains make influenza vaccine planning difficult. Concern about the emergence of new influenza pandemic provides subject for developing a universal influenza vaccine to be most effective in preventing influenza A either by targeting the HA or other viral proteins. The recombinant and synthetic antigens used in influenza vaccine research and development are generally less immunogenic and need to incorporate novel adjuvants with modified delivery carriers to develop broad-protective vaccines.</div>
Influenza virus, vaccine, adjuvant, delivery system
33
40
http://journal.isv.org.ir/browse.php?a_code=A-10-134-2&slc_lang=en&sid=1
Maryam
Ahmadi
m.ahmadi@rvsri.ac.ir
10031947532846006739
10031947532846006739
No
Razi Vaccine & Serum Research Institute
Shahla
Shahsavandi
s.shahsavandi@rvsri.ac.ir
10031947532846006740
10031947532846006740
Yes
Razi Vaccine & Serum Research Institute