en تخصصي Special پژوهشي Original article <div><strong>Background and Aims:</strong> EBV infection usually occurs in humans and is very common. Sero-epidemiological surveys show that over 95% of adults worldwide are faced with EBV virus. The Epstein-Barr virus causes infectious mononucleosis and its association with a number of human cancers, including Hodgkin&#39;s lymphoma, non-Hodgkin lymphoma (especially lymphoma BL), nasopharyngeal carcinoma, gastric carcinoma and breast cancer has been established.<br> <strong>Materials and Methods:</strong> This study was conducted cross-sectional. This study was designed to determine the presence of the Epstein-Barr virus genome in tissue samples of patients with Hodgkin lymphoma and non-Hodgkins. In this study, 40 samples of patients with non-Hodgkin&#39;s lymphoma and Hodgkin&#39;s disease, while had been kept in archives of the Shahid Bahonar Hospital, Afzalipour Hospital and Payambar-e-Azam Hospital of Kerman were examined by real-time PCR technique. The data collected by SPSS software and chi-square test were analyzed.<br> <strong>Results:</strong> The prevalence of EBV in patients in this study was 5/27% of the 40 sample, of which 20 cases were of Hodgkin lymphoma and 20 cases were of non-Hodgkin lymphoma. No significant correlation was found between the prevalence of EBV in Hodgkin and non-Hodgkin lymphoma. There was also no correlation between men and women of different ages for the presence of EBV DNA in patients samples (P>0.05).<br> <strong>Conclusions: </strong>EBV DNA associated with the tumor could be detected by molecular methods which are useful for the diagnosis of EBV-associated diseases, also biological factors such as age, sex, health status, social and economic factors in the pathogenesis of EBV and its relationship to lymphoma was not observed.</div> Hodgkin's lymphoma, Non-Hodgkin`s lymphoma, Epstein-Barr Virus, Real -Time-PCR 1 7 http://journal.isv.org.ir/browse.php?a_code=A-10-157-1&slc_lang=en&sid=1 S Pourrezaei shahin.aghamiri@gmail.com 10031947532846006741 10031947532846006741 No Health Research Institute, Infectious and Tropical Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran A jafarpour aligafarpour10101370@yahoo.com 10031947532846006742 10031947532846006742 No Virology Division, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Sh Aghamiri POURREZAEIS@yahoo.com 10031947532846006743 10031947532846006743 No Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran Hamid Reza Molai HamidRezaMolai8585@gmail.com 10031947532846006744 10031947532846006744 No Virology Department, School of Medicine, Kerman University of Medical Sciences, Kerman, IR Iran Ali Mohammad Arabzadeh shehnitara1998@yahoo.com 10031947532846006745 10031947532846006745 Yes Virology Department, School of Medicine, Kerman University of Medical Sciences, Kerman, IR Iran T Shahani ToranShahani7575@gmail.com 10031947532846006746 10031947532846006746 No Virology Department, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran