en تخصصي Special پژوهشي Original article <div><strong>Background and Aims:</strong> The impact of <em>Borna Disease virus</em> (BDV) in Asian psychiatric patients remains to be clear. Epidemiological studies would help to understand the rate of BDV incidence among different groups of patients with psychiatric disorders.<br> Objectives: A systematic review and meta-analysis on risk of BDV among Asian psychiatric patients.<br> <strong>Materials and Methods:</strong> Literature review was performed on the BDV prevalence in Asia. Data, including both subjects&#39; characteristics and the epidemiology of the virus have been extracted and used for further meta-analysis on genomic and serological data. Odd ratio (OR) has been estimated by using comprehensive meta-analysis software V2. In this regard, I2 and Cochran&rsquo;s Q-value have been evaluated for heterogeneity. Odds ratio (OR) has been investigated by the confidence interval (CI) of 95%. The Funnel plot and Egger&rsquo;s and Begg&rsquo;s statistics were used for evaluating the publication bias. P-value less than 0.05 considered as significant.<br> <strong>Results:</strong> Data revealed higher incidence of BDV RNA (5.902 95% CI, 3.97-8.775) in psychiatric patients. Odd ratio was also higher in seropositive patients in comparison with control group (2.334 95% CI, 1.829-2.952). It was also found that ELISA and western-blot methods might over-estimate BDV existence in patients and cause heterogeneity. <strong>Conclusions: </strong>High prevalence of BDV in psychiatric patients was found in Asia. Furthermore, the results obtained by ELISA and western blot are not reliable enough, which might be resulted from cross-reactive or closely related antibodies in human body fluids.</div> Borna Disease Virus, Systematic review and meta-analysis, Comprehensive Meta-Analysis, Psychiatric Disorders, Schizophrenia, Bipolar disorder 6 19 http://journal.isv.org.ir/browse.php?a_code=A-10-99-3&slc_lang=en&sid=1 Alireza Mohebbi Mohebbi-a@goums.ac.ir 10031947532846006928 10031947532846006928 Yes Student Research Committee, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran Mohammad Yasaghi Mohammad.m@goums.ac.ir 10031947532846006929 10031947532846006929 No Student Research Committee, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran Zoleikha Mamizadeh Zlkhmamzde@gmail.com 10031947532846006930 10031947532846006930 No Department of Microbiology, Faculty of Advanced Sciences, Islamic Azad University, Tehran, Iran Ali Salehnia Ali.germany7@gmail.com 10031947532846006931 10031947532846006931 No Student Research Committee, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran Nazanin Lorestani Nazanin.lorestani@gmail.com 10031947532846006932 10031947532846006932 No Student Research Committee, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran Alijan Tabarraei Tabarraei@goums.ac.ir 10031947532846006933 10031947532846006933 No Department of Microbiology, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran