en تخصصي Special پژوهشي Original article <div><strong>Background and aims: </strong>The end of 2019 has marked the year, which the human population encountered a novel virus; SARS-CoV-2 that causes a disease namely COVID-19. Here we focused on the genome and protein mutations and subsequently suggested a new classification of the SARS-CoV-2.<br> <strong>Materials and Methods: </strong>Our study showed that some extra positions in the virus genome play a key role in the SARS-CoV-2 classification. Based on the analysis of the whole genome sequences of 93 viruses.<br> <strong>Results:</strong> mutations were classified into nine divisions including IA-1, IA-2, IA-3, IB, II, L1, L2, L3 and S. Totally, 279 mutations were found in the SARS-CoV-2 genomes. 24 mutations lead to the amino acid frame shifting, of which 15 mutations lead to positive frame shifting in amino acids sequences.<br> <strong>Conclusion: </strong>Sequence alignment of these positions with that of ancestors showed no change suggesting that they might have occurred in the SARS-CoV-2 genomes to adapt itself to humans.</div> SARS-coronavirus-2, COVID-19, classification, Phylogenetic tree analysis, Mutations, Evolution 7 14 http://journal.isv.org.ir/browse.php?a_code=A-10-268-1&slc_lang=en&sid=1 Alireza Sanchooli alirezasanchooli@yahoo.com 10031947532846007221 10031947532846007221 No Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran Mohammad Kazem Shahkarami shahkarami961@yahoo.com 10031947532846007222 10031947532846007222 No Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran Jose Thekkiniath jose.joshua@gmail.com 10031947532846007223 10031947532846007223 No Fuller Laboratories, 1312 East Valencia Drive, Fullerton, CA- 92831, USA Shahla Karimi Naghlani shahlaae57@yahoo.com 10031947532846007224 10031947532846007224 No Razi Vaccine and Serum Research Institute, Agricultura l Research, Education and Extension Organization (AREEO), Karaj, Iran Mahboubeh Kamali mahbube_kamali@yahoo.com 10031947532846007225 10031947532846007225 No Department of Biology, Islamic Azad University, North Tehran Branch, Tehran, Iran Mahdi Cheraghi m.cheraghi@rvsri.ac.ir 10031947532846007226 10031947532846007226 No Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran Mohammad Shojaei shojaei.mohamaddr@yahoo.com 10031947532846007227 10031947532846007227 Yes Razi Vaccine and Serum Research Institute, Agricultural Research, Education and Extension Organization (AREEO), Karaj, Iran