en عمومى General پژوهشي Original article <div style="border-bottom:solid windowtext 1.0pt; border-top:solid windowtext 1.0pt; border-left:none; border-right:none; padding:1.0pt 0in 1.0pt 0in"><span style="color:#000000;"><span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt">Background and Aims: </span></b><span style="font-size:11.0pt">Breast cancer is one of the most common malignancies and the most common cause of death in women worldwide. Recently, viral etiology theory has been proposed on the physiopathology of breast cancer.</span></span></span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span style="color:#000000;"><b><span style="font-size:11.0pt">Materials and Methods: </span></b></span><a name="_Hlk106352359"><span style="color:#000000;">This cross-sectional study evaluated the presence of the Human Herpes Virus-8 genome in 138 formalin-fixed and paraffin-embedded (FFPE) breast cancer tissues, using real-time PCR. All samples were collected from the department of pathology of Bahonar Hospital (Kerman, Iran) and sent to the virology laboratory of Kerman University of Medical sciences with appropriate conditions</span></a><span style="color:#000000;"><span style="font-size:11.0pt">.</span></span></span></span></span><br> <span style="color:#000000;"><span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt">Results:</span></b> Out of the 138 FFPE breast cancer tissues, 17(12.31%) were positive for HHV8. Among the HHV-8 positive samples, 58.8% were in the 41-60 years old age group. Among HHV-8 positive cases, 47.05% were an intermediate grade and 82.05% have involvement of 7-9 lymph nodes. Also, there was a significant relationship between age and breast cancer<span style="font-size:11.0pt">.</span></span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt">Conclusion: </span></b>The results of this study showed that the prevalence of HHV-8 infection in patients with breast cancer is high and may be associated with an increased risk of breast cancer<span style="font-size:11.0pt">.</span></span></span></span></span></div> Human Herpesvirus 8, HHV-8, Breast Cancer 42 47 http://journal.isv.org.ir/browse.php?a_code=A-10-281-1&slc_lang=en&sid=1 elaheh fozuni elahehfozouni@yahoo.com 10031947532846006584 10031947532846006584 No Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran. Seyed Mohammad Ali Arabzadeh a_arabzadeh@kmu.ac.ir 10031947532846006585 10031947532846006585 No Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran. Hamid Reza Mollaei hamid2008kmu@gmail.com 10031947532846006586 10031947532846006586 No Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran. • Maryam Iranpour dr.iranpour.86@gmail.com 10031947532846006587 10031947532846006587 No Pathology and Stem Cell Research Center, Department of Pathology, kerman University of Medical Science, Kerman, Iran Reza Malekpour Afshar malekpour@kmu.ac.ir 10031947532846006588 10031947532846006588 Yes Pathology and Stem Cell Research Center, Department of Pathology, kerman University of Medical Science, Kerman, Iran