Iranian Journal of Virology
مجله ویروس شناسی ایران
Iran J Virol
Medical Sciences
http://journal.isv.org.ir
1
admin
1735-5680
2588-5030
10.21859/isv
en
jalali
1401
3
1
gregorian
2022
6
1
16
1
online
1
fulltext
en
Seroprevalence of Herpes Simplex Virus Types 1 & 2 (HSV 1,2) in Subjects with Multiple Sclerosis: A Case Control Study
عمومى
General
پژوهشي
Original article
<div style="border-bottom:solid windowtext 1.0pt; border-top:solid windowtext 1.0pt; border-left:none; border-right:none; padding:1.0pt 0in 1.0pt 0in"><span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt">Background and Aims: </span></b><span style="font-size:11.0pt">Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) in genetically susceptible individuals with various causes. Infections such as viral infections are suggested as potential underlying factors in the development of MS. Many studies have indicated the possible role of Herpes simplex virus (HSV) in the pathogenesis of MS. The current study aimed to evaluate anti-HSV type 1 and type 2 IgG Immunoglobulin of patients with MS.</span></span></span></span><br>
<span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt">Materials and Methods: </span></b><span style="font-size:11.0pt">In this assessment, serological samples of 38 patients with MS who were referred to the Neurology Department of Ghaem Hospital of Mashhad were compared with the control group; 41 patients from other Departments of Ghaem Hospital who did not have any signs of MS disease. Samples were evaluated for presence of antibody to HSV type 1 and type 2 by the Enzyme-linked immunosorbent assay (ELISA).</span></span></span></span><br>
<span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt">Results:</span></b><span style="font-size:11.0pt"> 29 patients with MS (76.3%) were positive, and 9 patients (23.7%) were negative for anti-HSV IgG antibody. In the control group, 36 samples (87.8%) were positive and 5 (12.2%) were negative for anti-HSV IgG antibody. Therefore, we found no correlation between HSV infection and MS. Although job distribution and MS did show an association in our study (P=0.034).</span></span></span></span><br>
<span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt">Conclusion: </span></b><span style="font-size:11.0pt">Despite all the studies confirming the connection between HSV and MS disease, in this assessment, no relation between infection with Herpes Simplex Virus and Multiple sclerosis was observed</span><span style="font-size:11.0pt">.</span></span></span></span></div>
Herpes Simplex Virus, Multiple Sclerosis, IgG antibody
48
53
http://journal.isv.org.ir/browse.php?a_code=A-10-298-1&slc_lang=en&sid=1
Arastoo
Vojdani
vejdaniA4001@mums.ac.ir
10031947532846006589
10031947532846006589
No
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Amir
Jalali
jalalia911@mums.ac.ir
10031947532846006590
10031947532846006590
No
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
Reza
Boostani
boostanir@mums.ac.ir
10031947532846006591
10031947532846006591
No
Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Morteza
Saeidi
saeidim@mums.ac.ir
10031947532846006592
10031947532846006592
No
Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
Arian
Amali
Arianamali77@yahoo.com
10031947532846006593
10031947532846006593
No
Student Research Committee, Paramedical Department, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran
Mohammad Reza
Mardani
Mardanimr4001@mums.ac.ir
10031947532846006594
10031947532846006594
No
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ahmad
Taherpoor
Taherpoura4001@mums.ac.ir
10031947532846006595
10031947532846006595
No
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Aida
Gholoobi
gholoubiad@mums.ac.ir
10031947532846006596
10031947532846006596
No
Metabolic Syndrome Research Center and Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Amin
Hooshyar Chechaklou
Amin.hooshyar@ymail.com
10031947532846006597
10031947532846006597
No
Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mojtaba
Meshkat
Mesh6280@gmail.com
10031947532846006598
10031947532846006598
No
Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran.
Samaneh
Abolbashari
abolbasharis1@mums.ac.ir
10031947532846006599
10031947532846006599
No
Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Zahra
Meshkat
meshkatz@mums.ac.ir
10031947532846006600
10031947532846006600
Yes
Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.