en تخصصي Special پژوهشي Original article <div style="border-bottom:solid windowtext 1.0pt; border-top:solid windowtext 1.0pt; border-left:none; border-right:none; padding:1.0pt 0in 1.0pt 0in"><span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt">Background and Aims: </span></b><span style="font-size:11.0pt"><span style="color:black">Avian Influenza (AI), an acute infectious disease of waterfowl, poultry, animals, and wild birds, is transmitted zoonotically to humans. There are some reports on the HPAI incidents in Iran: H5N8 and H5N1. The Iranian Veterinary Organization decided to vaccinate turkey flocks after the outbreak in high-risk provinces in Iran. The present work aimed to evaluate the vaccine&rsquo;s serum response in turkey flocks in the provinces of high risks.</span></span><span style="font-size:11.0pt"></span></span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt">Materials and Methods: </span></b><span style="font-size:11.0pt">From Tehran (no:1), Isfahan (no: 3), Zanjan (no: 1), and Mazandaran (no:1) provinces, six broiler turkey farms were chosen and received the H5 vaccine (two times of vaccination for each farm). From each flock, 15 blood samples were taken. The HI test was conducted using 4 HA units of the homologous antigen and a U-bottomed microtiter plate.</span></span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt">Results:</span></b><span style="font-size:11.0pt"> The antibody mean titers in the turkey farms previously receiving the vaccine were 1.23. However, they were 5.05 for those receiving the immunization twice (significant difference; p<0.05). Moreover, considering protection baseline 4, all flocks produced higher titer by injection of the vaccine twice.</span></span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b><span style="font-size:11.0pt">Conclusion: </span></b><span style="font-size:11.0pt">Integrating with other control measures like good monitoring and biosecurity programs, vaccination is an appropriate and robust instrument for supporting control programs or AI eradication in endemically infected countries. The regular post-vaccination surveillance was performed by the Iranian Veterinary Organization (IVO), and the flocks were evaluated for silent infections</span><span style="font-size:11.0pt">.</span></span></span></span></div> Avian Influenza, H5, Iran, broiler turkey, Vaccination 52 57 http://journal.isv.org.ir/browse.php?a_code=A-10-1-104&slc_lang=en&sid=1 Toohid Tolouei 10031947532846007198 10031947532846007198 No Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Mohammadreza Ghorani 10031947532846007199 10031947532846007199 No Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran. Hossein Hosseini 10031947532846007200 10031947532846007200 No Department of Poultry Diseases, Azad University, Karaj, Iran Hamideh Najafi 10031947532846007201 10031947532846007201 No Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Mohammad Reza Rezapanah 10031947532846007202 10031947532846007202 No Biological Control Research Department, Iranian Research Institute of Plant Protection (IRIPP), Agricultural Research, Education and Extension Organization (AREEO), Tehran, Iran. Center of Excellence for Organic Agriculture, Tehran, Iran. Iranian Network for Research in Viral Diseases, Tehran, Iran. Naser Sadri 10031947532846007203 10031947532846007203 No Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Zahra Ziafati Kafi 10031947532846007204 10031947532846007204 No Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Ali Hojabr Rajeoni 10031947532846007205 10031947532846007205 No Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Fahimeh Jamiri 10031947532846007206 10031947532846007206 No Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Soroush Sarmadi 10031947532846007207 10031947532846007207 No Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran. Arash Ghalyanchilangeroudi 10031947532846007208 10031947532846007208 Yes Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.