Iranian Journal of Virology
مجله ویروس شناسی ایران
Iran J Virol
Medical Sciences
http://journal.isv.org.ir
1
admin
1735-5680
2588-5030
10.21859/isv
en
jalali
1390
11
1
gregorian
2012
2
1
6
1
online
1
fulltext
en
Nucleoprotein (NP) Gene Based Phylogenetic Analysis of Iranian H9N2 Avian Influenza Isolates during 1998-2011
عمومى
General
پژوهشي
Original article
Background and Aims: Avian Influenza (AI) H9N2 subtype was first reported to infect turkeys in the United States in 1966 and has been panzootic in Eurasia. In Iran, the H9N2 virus was first isolated from broiler chickens in 1998 in Ghazvin province and it is the most prevalent subtype of influenza virus in poultry industry in Iran at the present time. Materials and Methods: In this study, we sequenced and analyzed Nucleoprotein (NP) gene of six AI H9N2 isolates from broiler farms of different parts of Iran from 1998 to 2011 to show probable changes since first advent. Results: Results indicate that nucleotide homology among these isolates with NP genes is between 91.8% to 98.8%. The divergences between isolates have significantly been increased since 2007.Iranian AI H9N2 Isolates based on NP gene divided in two distinct clusters according to their isolation year. Group 1 is located in Y-439 clade and Group 2 is located in G1 Clade. Iranian H9N2 isolates of avian influenza virus show more amino acid substitutions Compare to those found in human H9N2 isolates. Conclusion: The results shown here that further gene reassortment has occurred subsequent to the emergence of viruses in the Middle East highlights the potential for viruses to evolve rapidly.
Avian Influenza, H9N2, NP, Phylogenetic Study, Iran
36
42
http://journal.isv.org.ir/browse.php?a_code=A-10-1-65&slc_lang=en&sid=1
K
Majidzadeh- A
10031947532846003596
10031947532846003596
No
Iranian Centers for Breast Cancer (ICBC); Academic Center for Education, Culture and Research (ACECR), Tehran, Iran
M
Soleimani
10031947532846003597
10031947532846003597
No
TASNIM Biotechnology Research Center, AJA University of Medical Sciences, Tehran, Iran
V
Karimi
10031947532846003598
10031947532846003598
No
Departments of Clinical Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
A
Shojaee-Estabragh
10031947532846003599
10031947532846003599
No
QC Expert ,Pasteur Institute of Iran, Tehran, Iran
A
Fanni
10031947532846003600
10031947532846003600
No
Department of Microbiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
O
Mandegar
10031947532846003601
10031947532846003601
No
Department of Microbiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
A
Ghalyanchi-Langeroudi
10031947532846003602
10031947532846003602
Yes
Department of Microbiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran