%0 Journal Article %A Kiani, S.J %A Shamsi Shahrabadi, M %A Ataei, A %A Sajjadi, N %T Peganum harmala seed extract can prevent HSV-1 replication in vitro %J Iranian Journal of Virology %V 1 %N 4 %U http://journal.isv.org.ir/article-1-211-en.html %R 10.21859/isv.1.4.11 %D 2007 %K Peganum harmala L., Vero cells, TCID50, Cytotoxicity, %X Abstract: Peganum harmala L. (Zygophylaceae) has been used in a variety of practical applications in medical science. Our objective in the current study was to determine the effects of the seed extract on Herpes simplex virus type 1 (HSV-1) replication in Vero cells. Different concentrations (100, 500, 571, 667, 800 and 1000 µg/ml) of the extract were examined. Experiments were carried out using Vero cells. P.harmala seed extract was found to be non-toxic to Vero cells up to a concentration of 667 µg/ml. The antiviral activity of non-toxic concentration against HSV-1 was tested. The replication of HSV-1 was inhibited, indicating that the P.harmala L. extract contains an anti-HSV-1 substance. %> http://journal.isv.org.ir/article-1-211-en.pdf %P 11-16 %& 11 %! %9 %L A-10-43-24 %+ Department of Virology, Iran University of Medical Sciences, Tehran, IRAN %G eng %@ 1735-5680 %[ 2007