fa عمومى General پژوهشي Original article <div> <p>Herpes simplex virus (HSV) is one of the common pathogenic viruses of humans bing. This study aimed to determin anti-herpes virus activity of Mentha Piperita extracts in vitro. Mentha Piperita extracts can inhibit HSV infection when the cells treated before viral adsorbtion. HSV-1 were also inhibited by menthol after viral adsorption. HSV-1 viral particles were directly inhibited and viral yield was reduced when treated with Mentha Piperita extracts and menthol. Therefore, Mentha Piperita extracts and menthol showed anti-HSV activities at various stages of the viral replication cycle.</p> </div> Mentha Piperita, menthol, herpes simplex virus, virus replication, eye infection 35 41 http://journal.isv.org.ir/browse.php?a_code=A-10-1-94&slc_lang=fa&sid=1 Jalil Omidian 10031947532846003354 10031947532846003354 No Department of Ophthalmology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Fariba Sheikhi-Shooshtari 10031947532846003355 10031947532846003355 Yes Department of Ophthalmology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran Maryam Fazeli 10031947532846003356 10031947532846003356 No WHO Collaborating Center for Reference and Research on Rabies, Pasteur Institute of Iran, Tehran, Iran