Iranian Journal of Virology
مجله ویروس شناسی ایران
Iran J Virol
Medical Sciences
http://journal.isv.org.ir
1
admin
1735-5680
2588-5030
10.21859/isv
en
jalali
1396
6
1
gregorian
2017
9
1
11
3
online
1
fulltext
en
Investigation of the Relationship between HTLV-1 Infection and MMP-3 Gene Expression in HTLV-1 Positive Cardiac Patients
تخصصي
Special
پژوهشي
Original article
<div><strong>Background and Aims:</strong> Human T-lymphotropic virus type 1 (HTLV-1) is a member of retroviridae family that causes ATL and HAM/TSP. Many inflammatory diseases are associated with this virus, such as Sjögren's syndrome, Hashimoto's thyroiditis, Uveitis and also Atherosclerosis. HTLV-1 performs in long latency period and can activate the immune responses in coronary vessels. Activated immune system produces inflammatory factors such as TNF-α cytokine that can increase Matrix Metalloproteinases as a main factor in patients with coronary artery diseases (CAD). We aimed to determine the relation between this virus infection and MMP-3 expression in Atherosclerosis patients.<br>
<strong>Materials and Methods:</strong> 44 patients (13 individuals CAD+ HTLV-1+, 8 individuals CAD- HTLV-1+, 13 individuals CAD+ HTLV-1- and 10 individuals CAD- HTLV-1-) were selected and MMP-3 gene expression was measured by Real-time polymerase chain reaction. <strong>Results:</strong> There was no significant correlation between MMP-3 gene expression and HTLV-1 expression level in HTLV-1-positive cardiac and Atherosclerosis patients.</div>
<strong>Conclusions: </strong>Although the main risk factor in Atherosclerosis patients is MMP-3, despite our expectation, no significant correlation was observed in our statistical analysis within four examined groups (p≥0.05). This evaluation showed higher MMP-3gene expression but not significant in CAD+ HTLV-1+ group compared to CAD+ HTLV-1- group. The larger sample sizes may help to improve the outcome to reach a significant level.
HTLV-1, MMP-3, TNF-α, Atherosclerosis, Real-time PCR
13
18
http://journal.isv.org.ir/browse.php?a_code=A-10-140-1&slc_lang=en&sid=1
Mina
Mohammadhosayni
mobinhuseyni@yahoo.com
10031947532846006715
10031947532846006715
No
Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran
Fatemeh
Hajighasemi
hajghasemi@gmail.com
10031947532846006716
10031947532846006716
No
Department of Immunology, Faculty of Medicine, Shahed University, Tehran, Iran
Abdolrahim
Rezaee
RezaeeR@mums.ac.ir
10031947532846006717
10031947532846006717
No
Inflammation and Inflammatory Diseases Division, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Farnaz
Mozayani
MozayaniF881@gmail.com
10031947532846006718
10031947532846006718
No
Inflammation and Inflammatory Diseases Division, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Fatemeh Sadat
Mohammadi
Fs_mohamadi55@yahoo.com
10031947532846006719
10031947532846006719
No
Inflammation and Inflammatory Diseases Division, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Nastaran
Tarban
nastarantarban88@gmail.com
10031947532846006720
10031947532846006720
No
Department of Biology, Kish International Campus, University of Tehran, Kish, Iran
Navid
Momenifar
na.momenifar@gmail.com
10031947532846006721
10031947532846006721
No
Faculty of Basic Sciences and Advanced Technologies in Biology, Department of Cell and Molecular Biology Science, University of Science and Culture, ACECR, Tehran, Iran
Mehdi
Norouzi
mnorouzi@tums.ac.ir
10031947532846006722
10031947532846006722
Yes
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran