en تخصصي Special گزارش مورد Case report <div style="border-bottom:solid windowtext 1.0pt; border-top:solid windowtext 1.0pt; border-left:none; border-right:none; padding:1.0pt 0in 1.0pt 0in"><span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><span style="font-size:11.0pt">There have been several known neurologic manifestations of COVID-19, such as headache, anosmia, etc. Rare cases of restless legs syndrome (RLS) associated with the disease have been reported. Here, the authors describe a patient with six-day nighttime discomfort in both legs that improved with moving them, with dry cough and myalgia added to her symptoms and she was hospitalized due to low oxygen saturation and suspicion of COVID-19. During hospitalization, antiviral and anti-inflammatory drugs were used and after a short time of discharge, RLS was eliminated without any specific drug. We hypothesize that since angiotensin-converting enzyme (ACE2) is highly expressed in Substantia Nigra, SARS-Cov-2 may disturb iron metabolism and homeostasis of dopaminergic neurons which leads to the development of RLS and inflammation exacerbates the condition.</span></span></span></span></div> SARS-CoV-2, COVID-19, Restless legs syndrome, SubstantiaNigra, Sleep disorder. 86 89 http://journal.isv.org.ir/browse.php?a_code=A-10-317-1&slc_lang=en&sid=1 Atefeh Fakharian fakharian_2005@yahoo.com 10031947532846007590 10031947532846007590 No 1. Pulmonary Rehabilitation Research Center (PRRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Maryam Sadat Mirenayat Mirenayat_M@yahoo.com 10031947532846007591 10031947532846007591 No 1.Pulmonary Rehabilitation Research Center (PRRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Fahimeh Vahabizad Fahime.vahabizad@gmail.com 10031947532846007592 10031947532846007592 No Department of Neurology, Sina Hospital, Tehran University of Medical Science, Tehran, Iran. Masoume ZoghAli masoumehzoghali2020@gmail.com 10031947532846007593 10031947532846007593 Yes 1. Pulmonary Rehabilitation Research Center (PRRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2. Physical Medicine & Rehabilitation Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.