Iranian Journal of Virology

en Epidemiological Investigation of Adenovirus Infection in Individuals Presenting Acute Respiratory Manifestations at The Academic Medical Facilities تخصصي Special پژوهشي Original article <div style="border-bottom:solid windowtext 1.0pt; border-top:solid windowtext 1.0pt; border-left:none; border-right:none; padding:1.0pt 0in 1.0pt 0in">Background and Aims: Adenoviruses are dsDNA viruses known for causing respiratory, gastrointestinal, ocular, and genitourinary infections. Epidemiological insights are crucial for public health interventions. This study focuses on the epidemiology of adenoviruses in acute respiratory cases, aiming to enhance preventive and therapeutic strategies. Materials and Methods: This cross-sectional study was performed on collected throat swab samples from individuals under 19 with acute respiratory symptoms. Nested-PCR was used to detect adenovirus presence in 328 samples. DNA extraction, quality assessment, and statistical analyses were conducted to determine prevalence, clinical manifestations, in the papulation under study. Results: Among the 328 samples analyzed, 72 samples (22%) including 25 male and 47 female tested positive for adenovirus infection using Nested-PCR. Clinical symptoms evaluation revealed distinct manifestations. Fever was presented in 72.6% of cases, cough in 64.6%, and muscular pain in 64%. Gender differences emerged, with 56.3% of infected individuals being females and 34.7% males. Statistical analyses confirmed these associations, providing valuable insights into the prevalence and clinical aspects of adenovirus infections. Conclusion: The identification of distinct clinical manifestations, coupled with gender-specific prevalence, underscores the complexity of adenovirus infections. These findings contribute crucial knowledge to the understanding of adenovirus epidemiology, highlighting the need for targeted interventions and public health strategies to address their substantial burden on affected populations. Further research and ongoing surveillance are imperative for the effective management and mitigation of adenovirus-related respiratory diseases.</div> Adenoviruses, acute respiratory infections, epidemiology, public health, prevention. 23 29 http://journal.isv.org.ir/browse.php?a_code=A-10-305-2&slc_lang=en&sid=1 Fahime Edalat fa_edalat@yahoo.com 10031947532846007594 10031947532846007594 No Department of Bacteriology & Virology, Shiraz Medical School, Shiraz University of medical Sciences, Shiraz, Iran. Arash Letafati arashletafati@yahoo.com 10031947532846007595 10031947532846007595 No Department of Virology, Faculty of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Neda Pirbonyeh p.pirbonyeh@yahoo.com 10031947532846007596 10031947532846007596 No 1. Department of Bacteriology & Virology, Shiraz Medical School, Shiraz University of medical Sciences, Shiraz, Iran. 2. Microbiology Department, Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Hooman Kheradmandi hooman.kheradmandi@gmail.com 10031947532846007597 10031947532846007597 No School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Afagh Moattari moattaria@sums.ac.ir 10031947532846007598 10031947532846007598 Yes Department of Bacteriology & Virology, Shiraz Medical School, Shiraz University of medical Sciences, Shiraz, Iran.