Iranian Journal of Virology

en Prevalence of Human Coronaviruses NL63, HKU1, 229E, OC43, MERS, and SARS-CoV-2 among Hospitalized Patients with Acute Respiratory Infection in Tehran تخصصي Special پژوهشي Original article Abstract <div style="border-bottom:solid windowtext 1.0pt; border-top:solid windowtext 1.0pt; border-left:none; border-right:none; padding:1.0pt 0in 1.0pt 0in">Background and Aims: Coronaviruses cause upper respiratory ailments and sporadically lower tract sickness in vulnerable populations. This study examined the prevalence of six human coronaviruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), OC43, 229E, HKU1, NL63, and Middle East respiratory syndrome coronavirus (MERS-CoV) during the 2019 pandemic caused by SARS-CoV-2 in Tehran, Iran. Material and methods: Specimens were collected from 204 adult patients with acute respiratory illness. The specimens were examined for the presence of six human coronaviruses using consensus and subtype-specific Real-time reverse-transcription polymerase chain reaction (PCR) assays. The demographic and clinical characteristics associated with coronavirus infection were examined retrospectively. Results: Coronaviruses were identified in 204 adult patients. The gender ratio was 104/100 male and female, respectively. HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1, MERS-CoV, and SARS-CoV-2 were detected in 0.5%, 1.0%, 4.0%, 7.4%, 0.0%, and 22.5% of patients, respectively. The acute clinical features were similar across subtypes. There was no report of fatality incidence among the population during the investigation period. Conclusions: HCoVs could play a significant role in causing upper respiratory tract infections among adults and older children. Based on the findings of this study and those of others, more extensive studies using other diagnostic methods and higher sample sizes are suggested.</div>   Human coronavirus, Pandemic, Iran, Prevalence 9 14 http://journal.isv.org.ir/browse.php?a_code=A-10-352-1&slc_lang=en&sid=1 Seyed Jalal Kiani kiani.j@iums.ac.ir 10031947532846007816 10031947532846007816 No Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Atefeh Kachoei Mohaghgh a.mohaghegh91@gmail.com 10031947532846007817 10031947532846007817 No Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Masoud Eslami eslamimasoud1403@gmail.com 10031947532846007818 10031947532846007818 No Maham Foundation for Respiration Science (MFRS), Neuroscience Research Centre (NRS), Iran University of Medical Sciences, Tehran, Iran. Ahmad Tavakoli ahmad.tavakoli66@gmail.com 10031947532846007819 10031947532846007819 No Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases, Iran University of Medical Sciences, Tehran, Iran. Mohammad Hadi Karbalaie Niya mohamad.karbalai@yahoo.com 10031947532846007820 10031947532846007820 No Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Alireza Javan alirezajavan1365@gmail.com 10031947532846007821 10031947532846007821 No Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Sheyda Alizadeh alizadehsheyda1402@gmail.com 10031947532846007822 10031947532846007822 No Department of Bacteriology and Virology, Shiraz University of Medical Science, Shiraz, Iran zahra salavatiha z.salavatiha96@gmail.com 10031947532846007823 10031947532846007823 No Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Mahdieh Hosseini hoseini6694@yahoo.com 10031947532846007824 10031947532846007824 No Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. zahra Safaei zahra.safaie@hotmail.com 10031947532846007825 10031947532846007825 No Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Mohamadreza Rezvani mohamadrezarezvani574@gmail.com 10031947532846007826 10031947532846007826 No Department of Hematology and Blood Transfusion, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran. Seyed Hamidreza Monavari Monavari.hr@iums.ac.ir 10031947532846007827 10031947532846007827 Yes Department of Medical Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.