Iranian Journal of Virology

en Clinical Findings and Mortality Rate of Patients with Multiple Myeloma Following COVID-19 infection: Report from Iranian Network for Research in Viral Diseases (INRVD) تخصصي Special پژوهشي Original article <div style="border-bottom:solid windowtext 1.0pt; border-top:solid windowtext 1.0pt; border-left:none; border-right:none; padding:1.0pt 0in 1.0pt 0in">Abstract Background and Aims: COVID-19 is a viral disease that spreads easily, caused by the SARS-CoV-2 virus. This illness has led to a worldwide pandemic and has caused many human fatalities. Patients with cancer have a weakened immune system, which makes them more susceptible to various infections. In this research, we wanted to compare mortality, hospitalization rate, and clinical findings in multiple myeloma (MM) patients. Materials and Methods: This research examined the effect of COVID-19 on sixteen individuals diagnosed with MM. Four hospitals—Imam Khomeini, Rouhani, Shariati, and Sina—were included in the study. All participants in affiliated hospitals underwent Real-time PCR testing to determine whether they had a viral infection with SARS-CoV-2. According to Iranian CDC guidelines, the real-time reverse transcription-polymerase chain reaction (RT-PCR) test was performed on throat specimens using flocked swabs obtained immediately upon admission to confirm SARS-CoV-2 infection. Collaborative clinical virology necessitates the utilization of two pairs of primers, each designed to target two specific genes (the E gene and the RdRP gene). Results: Patients with MM were found to have a considerably higher risk of hospitalization and mortality from COVID-19, as per the study results. Common symptoms observed in MM patients with COVID-19 included fever (87.5%), cough (87.5%), and dyspnea (62.5%). Moreover, the study revealed a substantial 17-fold increase in the odds of MM patients with COVID-19 positive compared to their counterparts without COVID-19. Conclusion: The study results emphasize the critical significance of prompt identification of COVID-19 among patients with MM. It underscores the importance of implementing public health measures, vaccination efforts, and continued research to effectively prevent severe illness and fatalities related to COVID-19 within this vulnerable population. </div> Multiple Myeloma, COVID-19, SARS-CoV-2, Respiratory Infection, cancer 26 33 http://journal.isv.org.ir/browse.php?a_code=A-10-355-1&slc_lang=en&sid=1 Zahra Ghandehari ghandeharizahra1@gmail.com 10031947532846007795 10031947532846007795 No Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. Omid Salahi Ardekani omid.salahi23@gmail.com 10031947532846007796 10031947532846007796 No Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. Behnaz Hammami Behnaz.hamami1994@gmail.com 10031947532846007797 10031947532846007797 No Department of genetics and molecular biology, school of medicine, Isfahan University of Medical Sciences, Isfahan, Iran Mahya Arabi arabiimahya@gmail.com 10031947532846007798 10031947532846007798 No Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. Morteza Rajabi morteza.rajabi7575@gmail.com 10031947532846007799 10031947532846007799 No Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. Sara Shivaei sarashivaeii@gmail.com 10031947532846007800 10031947532846007800 No Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. Alireza Etrati Kooshali alireza.etrati@gmail.com 10031947532846007801 10031947532846007801 No Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. Melina Molaeian melina808050@gmail.com 10031947532846007802 10031947532846007802 No Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Mehdi Fazeli Mohammadmehdifazeli80@gmail.com 10031947532846007803 10031947532846007803 No Department of Virology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Fateme Nurzad Fatemehnoorzad77@gmail.com 10031947532846007804 10031947532846007804 No Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. Arash Letafati arashletafati@yahoo.com 10031947532846007805 10031947532846007805 No Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran Mohammad Mahdi Behzadifar m.mahdibehzadifar81@gmail.com 10031947532846007806 10031947532846007806 No Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. Sheida Sarrafzadeh shsarafzadeh@gmail.com 10031947532846007807 10031947532846007807 No Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran. Mehdi Norouzi mnorouzi@tums.ac.ir 10031947532846007808 10031947532846007808 Yes Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran