Background and Aims: There is no data about JC virus genotypes in Iran. Due to the association of some genotypes of JC virus with PML (Progressive Multifocal Leukoencephalopathy) and also for the fact that some genotypes are more likely to be associated with certain diseases, such as cancer, the importance of this research is highlighted. The aim of this study was to determine the genotype of JC virus in northeastern Iran to find any different genotype in different tissues.
Materials and Methods: Twenty two colorectal tissue samples were collected from colorectal cancer patients and 19 urine samples were collected from healthy individuals. After genomic extraction, PCR was applied to amplify the desired gene region for genotyping. The reported sequences were compared with sequences recorded in NCBI database. The 100% match was observed in most of the samples.
Results: In general, 12 urine samples and 17 tissue samples were in type 1 and 3 urine specimens belonged to type 2, and 5 tissue samples and 4 urine specimens were also found in type 3.
Conclusions: According to the statistical analysis, there was no correlation between urinary tract genotypes and tissue samples. Genotype 2 was observed only in urine specimens but not tissue samples. The most common genotype in this study was Type-1 and then Type-3. No other genotype was observed in this study.