:: دوره 11، شماره 4 - ( 9-1396 ) ::
جلد 11 شماره 4 صفحات 1-7 برگشت به فهرست نسخه ها
Evaluation of Epstein - Barr virus Frequency in Paraffin-Embedded Tissues of Hodgkin and Non-Hodgkin Lymphoma Patients in Kerman Province
چکیده:   (631 مشاهده)
Background and Aims: EBV infection usually occurs in humans and is very common. Sero-epidemiological surveys show that over 95% of adults worldwide are faced with EBV virus. The Epstein-Barr virus causes infectious mononucleosis and its association with a number of human cancers, including Hodgkin's lymphoma, non-Hodgkin lymphoma (especially lymphoma BL), nasopharyngeal carcinoma, gastric carcinoma and breast cancer has been established.
Materials and Methods: This study was conducted cross-sectional. This study was designed to determine the presence of the Epstein-Barr virus genome in tissue samples of patients with Hodgkin lymphoma and non-Hodgkins. In this study, 40 samples of patients with non-Hodgkin's lymphoma and Hodgkin's disease, while had been kept in archives of the Shahid Bahonar Hospital, Afzalipour Hospital and Payambar-e-Azam Hospital of Kerman were examined by real-time PCR technique. The data collected by SPSS software and chi-square test were analyzed.
Results: The prevalence of EBV in patients in this study was 5/27% of the 40 sample, of which 20 cases were of Hodgkin lymphoma and 20 cases were of non-Hodgkin lymphoma. No significant correlation was found between the prevalence of EBV in Hodgkin and non-Hodgkin lymphoma. There was also no correlation between men and women of different ages for the presence of EBV DNA in patients samples (P>0.05).
Conclusions: EBV DNA associated with the tumor could be detected by molecular methods which are useful for the diagnosis of EBV-associated diseases, also biological factors such as age, sex, health status, social and economic factors in the pathogenesis of EBV and its relationship to lymphoma was not observed.
متن کامل [PDF 458 kb]   (88 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: ۱۳۹۷/۵/۲۳ | پذیرش: ۱۳۹۷/۱۱/۶ | انتشار: ۱۳۹۷/۱۱/۶


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دوره 11، شماره 4 - ( 9-1396 ) برگشت به فهرست نسخه ها