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Iran J Virol 2017, 11(4): 1-7 Back to browse issues page
Evaluation of Epstein - Barr virus Frequency in Paraffin-Embedded Tissues of Hodgkin and Non-Hodgkin Lymphoma Patients in Kerman Province
S Pourrezaei , A Jafarpour , Sh Aghamiri , Hamid Reza Molai , Ali Mohammad Arabzadeh , T Shahani
Virology Department, School of Medicine, Kerman University of Medical Sciences, Kerman, IR Iran
Abstract:   (1700 Views)
Background and Aims: EBV infection usually occurs in humans and is very common. Sero-epidemiological surveys show that over 95% of adults worldwide are faced with EBV virus. The Epstein-Barr virus causes infectious mononucleosis and its association with a number of human cancers, including Hodgkin's lymphoma, non-Hodgkin lymphoma (especially lymphoma BL), nasopharyngeal carcinoma, gastric carcinoma and breast cancer has been established.
Materials and Methods: This study was conducted cross-sectional. This study was designed to determine the presence of the Epstein-Barr virus genome in tissue samples of patients with Hodgkin lymphoma and non-Hodgkins. In this study, 40 samples of patients with non-Hodgkin's lymphoma and Hodgkin's disease, while had been kept in archives of the Shahid Bahonar Hospital, Afzalipour Hospital and Payambar-e-Azam Hospital of Kerman were examined by real-time PCR technique. The data collected by SPSS software and chi-square test were analyzed.
Results: The prevalence of EBV in patients in this study was 5/27% of the 40 sample, of which 20 cases were of Hodgkin lymphoma and 20 cases were of non-Hodgkin lymphoma. No significant correlation was found between the prevalence of EBV in Hodgkin and non-Hodgkin lymphoma. There was also no correlation between men and women of different ages for the presence of EBV DNA in patients samples (P>0.05).
Conclusions: EBV DNA associated with the tumor could be detected by molecular methods which are useful for the diagnosis of EBV-associated diseases, also biological factors such as age, sex, health status, social and economic factors in the pathogenesis of EBV and its relationship to lymphoma was not observed.
Keywords: Hodgkin's lymphoma, Non-Hodgkin`s lymphoma, Epstein-Barr Virus, Real -Time-PCR
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Type of Study: Original article | Subject: Special
Received: 2018/08/14 | Accepted: 2019/01/26 | Published: 2019/01/26
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Pourrezaei S, jafarpour A, Aghamiri S, Molai H R, Arabzadeh A M, Shahani T. Evaluation of Epstein - Barr virus Frequency in Paraffin-Embedded Tissues of Hodgkin and Non-Hodgkin Lymphoma Patients in Kerman Province. Iran J Virol. 2017; 11 (4) :1-7
URL: http://journal.isv.org.ir/article-1-331-en.html

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