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:: Volume 8, Issue 2 And 3 (11-2014) ::
Iran J Virol 2014, 8(2 And 3): 49-54 Back to browse issues page
Comparison of clinico - pathological changes in SPF chickens infected with different Iranian genotypes of infectious bronchitis virus
Hamide Najafi, Arash Ghalyanchi-Langeroudi, Masoud Hashemzadeh *, Omid Madadgar, Vahid Karimi, Reza Khaltabadi-Farahani, Hossein Maghsoudlo
Department of Research and Production of Poultry Viral Vaccine, Razi Vaccine and Serum Research Institute, Karaj, Iran
Abstract:   (4088 Views)

Introduction: Infectious bronchitis (IB), caused by infectious bronchitis virus (IBV), is an acute and highly contagious disease in chickens. IBV is mainly considered a respiratory infection, other clinical manifestations, including renal, enteric and reproductive signs can be observed. Aim: Since there has been no study on evaluation of changes in biochemical parameters during IB infection, this study designed to assess the serum biochemical factors in experimentally infected chicks with two IBV isolates. Methods: Two groups of 14-day-old SPF chickens were infected with two different isolates of IBV, Variant-2 like and IR-1 like genotypes respectively (35 chicks in each group). In addition, a group of 35 chickens remained non-infected as a control group. On days 1, 3, 5, 7, 14 and 21 and 28 post infection the sera of both infected groups and un-inoculated control group was collected to measure the biochemical factors, including uric acid, creatinine, alanine amino transferase (ALT) and aspartate amino transferase (AST) using a standard auto analyzer. We used multiple comparison ANOVA followed by a post-hoc test, (Level of significance <0.05). Results: There were no significant differences between evaluated parameters of each infected group in comparison with the control group. Conclusion: No changes were seen in serum factor levels between control and infected groups. In an experimental disease, there was no other infection to superimpose on IBV, so acute IBV infection was not strong enough to cause hepatic dysfunction or renal failure.

Keywords: ClinicoPathological changes, Chickens, Infectious bronchitis virus
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Type of Study: Original article | Subject: Special
Received: 2015/06/26 | Accepted: 2016/01/26 | Published: 2016/01/26
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Najafi H, Ghalyanchi-Langeroudi A, Hashemzadeh M, Madadgar O, Karimi V, Khaltabadi-Farahani R et al . Comparison of clinico - pathological changes in SPF chickens infected with different Iranian genotypes of infectious bronchitis virus. Iran J Virol 2014; 8 (2 and 3) :49-54
URL: http://journal.isv.org.ir/article-1-138-en.html

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