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:: Volume 1, Issue 4 (11-2007) ::
Iran J Virol 2007, 1(4): 11-16 Back to browse issues page
Peganum harmala seed extract can prevent HSV-1 replication in vitro
S.J Kiani *, M Shamsi Shahrabadi, A Ataei, N Sajjadi
Department of Virology, Iran University of Medical Sciences, Tehran, IRAN
Abstract:   (3438 Views)

Abstract: Peganum harmala L. (Zygophylaceae) has been used in a variety of practical applications in medical science. Our objective in the current study was to determine the effects of the seed extract on Herpes simplex virus type 1 (HSV-1) replication in Vero cells. Different concentrations (100, 500, 571, 667, 800 and 1000 µg/ml) of the extract were examined. Experiments were carried out using Vero cells. P.harmala seed extract was found to be non-toxic to Vero cells up to a concentration of 667 µg/ml. The antiviral activity of non-toxic concentration against HSV-1 was tested. The replication of HSV-1 was inhibited, indicating that the P.harmala L. extract contains an anti-HSV-1 substance. 

Keywords: Peganum harmala L., Vero cells, TCID50, Cytotoxicity
Full-Text [PDF 332 kb]   (1860 Downloads)    
Subject: Special
Received: 2016/08/27 | Accepted: 2016/08/27 | Published: 2016/08/27
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Kiani S, Shamsi Shahrabadi M, Ataei A, Sajjadi N. Peganum harmala seed extract can prevent HSV-1 replication in vitro. Iran J Virol 2007; 1 (4) :11-16
URL: http://journal.isv.org.ir/article-1-211-en.html

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