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:: Volume 10, Issue 2 And 3 (9-2016) ::
Iran J Virol 2016, 10(2 And 3): 31-39 Back to browse issues page
The comparative analysis of the protease molecule structure of the Human lymphotropic virus type-1 (HTLV-1)
Nastaran Tarban, Mehran Habibi Rezaei, Mina Shafifar, Mina Mohammad hosayni, SeyedAbdolrahim Rezaee, Seyed Mohammad Jazayeri, Mehdi Norouzi *
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (3540 Views)
Background and Aims: Human lymphotropic virus type-1 (HTLV-1) causes various diseases such as adult T-cell leukemia/lymphoma (ATLL) and HTLV-1 associated myelopathy/tropical spastic paraperesis (HAM / TSP) in humans. The main goal of this study is to compare Iranian protease subtypes structure of this virus (HTLV-1) to samples collected from other part of world in order to understand their differences.
Materials and Methods: During 1394 -1395, 10 blood samples taken from HTLV-1 virus infected individuals. Samples went through polymerase chain reaction (PCR) process.The obtained products were sequenced and phylogenetic analysis were done. The second and third structures of these sequences were obtained by using a specialized websites.
Results: The Iranian samples were completely exposed in to the cluster of Cosmopolitan subtype. The result of first structure alignment of protease protein in different subtypes of the virus, suggested some differences in the gene of interest. The conversion of the first structure to second and third structures and respectively pairwise and multiple alignment showed no significant difference in the protease protein conformation.
Conclusions: The comparison of HTLV-1 virus protease protein from Iran and other sequences in the world which were obtained from GenBank shows no significant dissimilarity. This dissimilarity help to design the production of the drug. Therefore, future studies can be targeting a part of the protein and generalize the treatment outcomes to all subtypes circulating. This comparison have beneficiary effect in making the right medication that inhibit the subtypes of the virus in treatment studies of disease developed by this virus.
Keywords: Human lymphotropic virus type -1 (HTLV-1), protease, homology modeling
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Type of Study: Original article | Subject: General
Received: 2017/05/20 | Accepted: 2017/07/29 | Published: 2017/07/29
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tarban N, Habibi Rezaei M, Shafifar M, Mohammad hosayni M, Rezaee S, Jazayeri S M et al . The comparative analysis of the protease molecule structure of the Human lymphotropic virus type-1 (HTLV-1). Iran J Virol 2016; 10 (2 and 3) :31-39
URL: http://journal.isv.org.ir/article-1-278-en.html

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Volume 10, Issue 2 And 3 (9-2016) Back to browse issues page
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