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:: Volume 11, Issue 3 (9-2017) ::
Iran J Virol 2017, 11(3): 13-18 Back to browse issues page
Investigation of the Relationship between HTLV-1 Infection and MMP-3 Gene Expression in HTLV-1 Positive Cardiac Patients
Mina Mohammadhosayni, Fatemeh Hajighasemi, Abdolrahim Rezaee, Farnaz Mozayani, Fatemeh Sadat Mohammadi, Nastaran Tarban, Navid Momenifar, Mehdi Norouzi
Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (2614 Views)
Background and Aims: Human T-lymphotropic virus type 1 (HTLV-1) is a member of retroviridae family that causes ATL and HAM/TSP. Many inflammatory diseases are associated with this virus, such as Sjögren's syndrome, Hashimoto's thyroiditis, Uveitis and also Atherosclerosis. HTLV-1 performs in long latency period and can activate the immune responses in coronary vessels. Activated immune system produces inflammatory factors such as TNF-α cytokine that can increase Matrix Metalloproteinases as a main factor in patients with coronary artery diseases (CAD). We aimed to determine the relation between this virus infection and MMP-3 expression in Atherosclerosis patients.
Materials and Methods: 44 patients (13 individuals CAD+ HTLV-1+, 8 individuals CAD- HTLV-1+, 13 individuals CAD+ HTLV-1-      and 10 individuals CAD- HTLV-1-) were selected and MMP-3 gene expression was measured by Real-time polymerase chain reaction. Results: There was no significant correlation between MMP-3 gene expression and HTLV-1 expression level in HTLV-1-positive cardiac and Atherosclerosis patients.
Conclusions: Although the main risk factor in Atherosclerosis patients is MMP-3, despite our expectation, no significant correlation was observed in our statistical analysis within four examined groups (p≥0.05). This evaluation showed higher MMP-3gene expression but not significant in CAD+ HTLV-1+ group compared to CAD+ HTLV-1- group. The larger sample sizes may help to improve the outcome to reach a significant level.
Keywords: HTLV-1, MMP-3, TNF-α, Atherosclerosis, Real-time PCR
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Type of Study: Original article | Subject: Special
Received: 2018/06/14 | Accepted: 2018/09/7 | Published: 2018/09/7
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Mohammadhosayni M, Hajighasemi F, Rezaee A, Mozayani F, Mohammadi F S, Tarban N, et al . Investigation of the Relationship between HTLV-1 Infection and MMP-3 Gene Expression in HTLV-1 Positive Cardiac Patients. Iran J Virol. 2017; 11 (3) :13-18
URL: http://journal.isv.org.ir/article-1-327-en.html

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