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Iran J Virol 2021, 15(1): 61-67 Back to browse issues page
A Brief Review on the Advancement of the Molecular and Serological Diagnosis of SARS-CoV-2
Alireza Tabibzadeh , Ahmad Tavakoli, Parstoo Yousefi, Saber Soltani, Somayeh Sadat Moochani, Saeedeh Abbasi, Seyed Hamidreza Monavari *
Department of Virology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (916 Views)
The novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is causative agent for coronavirus disease 2019 (COVID-19) since the 2019 December. Human coronaviruses are classified in Nidovirales order and Coronavirdiae family. This family includes four genera. The SARS-CoV-2 is a member of Betacoronavirus genera and Sarbecovirus linage (linage B). There is a great number of conducted researches for the therapeutic options, epidemiological aspects, clinical and radiological features and molecular or serological diagnosis for the SARS-CoV-2. There is a verity of the commercially available serological and molecular kits for COVID-19 diagnosis. Also, the WHO recommended molecular approaches for the diagnosis. This recommended list contains different primer and probe sets for SARS-CoV-2 diagnosis and different authors assessed the specificity and sensitivity of this primer and probe sets. In this review, we tried to gather comprehensive information about these diagnosis strategies. Also, there are some studies focused on the antibody response to SARS-CoV-2. By considering the growing amount of the available researches in the field of the serological and molecular diagnosis in SARS-CoV-2 detection, current study was aimed to briefly review the most important advancements in this particular subject area.
Keywords: SARS-CoV-2, COVID-19, PCR, Serology, Antibody, Diagnosis
Full-Text [PDF 414 kb]   (332 Downloads)    
Type of Study: Review article | Subject: Special
Received: 2020/05/26 | Accepted: 2021/07/4 | Published: 2021/06/20
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Tabibzadeh A, tavakoli A, Yousefi P, Soltani S, Moochani S S, Abbasi S et al . A Brief Review on the Advancement of the Molecular and Serological Diagnosis of SARS-CoV-2. Iran J Virol 2021; 15 (1) :61-67
URL: http://journal.isv.org.ir/article-1-388-en.html

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