:: Volume 16, Issue 1 (6-2022) ::
Iran J Virol 2022, 16(1): 42-47 Back to browse issues page
Prevalence of Human Herpes Virus-8 Infection Among Women with Breast Cancer
Elaheh Fozuni, Seyed Mohammad Ali Arabzadeh, Hamid Reza Mollaei, • Maryam Iranpour, Reza Malekpour Afshar *
Pathology and Stem Cell Research Center, Department of Pathology, kerman University of Medical Science, Kerman, Iran
Abstract:   (898 Views)
Background and Aims: Breast cancer is one of the most common malignancies and the most common cause of death in women worldwide. Recently, viral etiology theory has been proposed on the physiopathology of breast cancer.
Materials and Methods: This cross-sectional study evaluated the presence of the Human Herpes Virus-8 genome in 138 formalin-fixed and paraffin-embedded (FFPE) breast cancer tissues, using real-time PCR. All samples were collected from the department of pathology of Bahonar Hospital (Kerman, Iran) and sent to the virology laboratory of Kerman University of Medical sciences with appropriate conditions.
Results: Out of the 138 FFPE breast cancer tissues, 17(12.31%) were positive for HHV8. Among the HHV-8 positive samples, 58.8% were in the 41-60 years old age group. Among HHV-8 positive cases, 47.05% were an intermediate grade and 82.05% have involvement of 7-9 lymph nodes. Also, there was a significant relationship between age and breast cancer.
Conclusion: The results of this study showed that the prevalence of HHV-8 infection in patients with breast cancer is high and may be associated with an increased risk of breast cancer.
Keywords: Human Herpesvirus 8, HHV-8, Breast Cancer
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Type of Study: Original article | Subject: General
Received: 2021/06/6 | Accepted: 2021/08/14 | Published: 2022/06/30

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Volume 16, Issue 1 (6-2022) Back to browse issues page