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Seroprevalence of Herpes Simplex Virus Types 1 & 2 (HSV 1,2) in Subjects with Multiple Sclerosis: A Case Control Study
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Arastoo Vojdani   , Amir Jalali , Reza Boostani , Morteza Saeidi , Arian Amali , Mohammad Reza Mardani , Ahmad Taherpoor , Aida Gholoobi , Amin Hooshyar Chechaklou , Mojtaba Meshkat , Samaneh Abolbashari , Zahra Meshkat *  |
| Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. |
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Abstract: (1568 Views) |
Background and Aims: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS) in genetically susceptible individuals with various causes. Infections such as viral infections are suggested as potential underlying factors in the development of MS. Many studies have indicated the possible role of Herpes simplex virus (HSV) in the pathogenesis of MS. The current study aimed to evaluate anti-HSV type 1 and type 2 IgG Immunoglobulin of patients with MS.
Materials and Methods: In this assessment, serological samples of 38 patients with MS who were referred to the Neurology Department of Ghaem Hospital of Mashhad were compared with the control group; 41 patients from other Departments of Ghaem Hospital who did not have any signs of MS disease. Samples were evaluated for presence of antibody to HSV type 1 and type 2 by the Enzyme-linked immunosorbent assay (ELISA).
Results: 29 patients with MS (76.3%) were positive, and 9 patients (23.7%) were negative for anti-HSV IgG antibody. In the control group, 36 samples (87.8%) were positive and 5 (12.2%) were negative for anti-HSV IgG antibody. Therefore, we found no correlation between HSV infection and MS. Although job distribution and MS did show an association in our study (P=0.034).
Conclusion: Despite all the studies confirming the connection between HSV and MS disease, in this assessment, no relation between infection with Herpes Simplex Virus and Multiple sclerosis was observed. |
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| Keywords: Herpes Simplex Virus, Multiple Sclerosis, IgG antibody |
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Full-Text [PDF 420 kb]
(1023 Downloads)
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Type of Study: Original article |
Subject:
General
Received: 2021/12/10 | Accepted: 2022/07/18 | Published: 2022/06/30
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