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Showing 5 results for Blood Donor
Z Sharifi , M Mahmoudian Shooshtari ,
Volume 1, Issue 4 (11-2007)
Abstract
Abstract: Genotyping of the hepatitis C virus (HCV) is important for designing therapeutic strategies and regional specific diagnostic assays. The aim of this study was to identify the HCV genotypes in HCV infected blood donors. This is the first report on HCV genotypes in blood donors in Iran. In this cross-sectional study, 103 blood donors with hepatitis C were investigated for HCV genotypes. HCV genotyping was carried out using type-specific primers from the core region of the viral genome. From 103 blood donors, only96 cases had genotypes which could be typed. The highest frequency genotype 1a, with 53 (51.5%) of subjects. Genotype 3a and 1b were the other frequent genotypes with 39 (37.9 %) and 4 (3.9%) subjects, respec-tively. These results indicate that the dominant HCV genotypes among blood donors were 1a, 3a and 1b respectively. It was also noticed that more of the blood donors infected with genotypes 1a and 3a had history of intravenous drug abuse and tattooing.
Zohreh Sharifi, Mahmood Mahmoodian Shooshtari,
Volume 2, Issue 1 (2-2008)
Abstract
Shahab Falahi, Farzaneh Sabahi, Majid Zainali, Jalal Kiani, Javad Ranjbari,
Volume 2, Issue 3 (12-2008)
Abstract
M Mahmoodian-Shooshtari , Z Sharifi,
Volume 5, Issue 2 (5-2011)
Abstract
Background and Aims: Human parvovirus B19, a member of the parvoviridae family, with single-stranded DNA is a very minute non-enveloped virus. B 19 virus is mostly transmitted via the respiratory tract but some studies have been reported which B19 virus can be transmitted through blood and/or blood products. The aim of this study was to evaluate the prevalence of B19 among blood donors in Tehran. Methods: In this cross-sectional study, the collection of samples was performed in Tehran blood transfusion center for a period of 6 months, from March 2005 through August 2006. Sera of 1640 blood donors who were negative for human immunodeficiency virus ( HIV), hepatitis B surface antigen (HBs Ag) and hepatitis C virus (HCV) were tested for immunoglobulin G (IgG) and immunoglobulin M (IgM) anti-B19 using Enzyme Linked Immunosorbent Assay (ELISA). Then, all of the sera were tested for presence of B19 DNA through semi-nested Polymerase Chain Reaction (PCR). Results: Out of 1640 blood donors, 8 (0.5%) subjects had IgM antibody thereby being reported positive 676 subjects (41.2%,) confidential intervals (CIs 95%= 42.7-50) were positive for anti-B19 IgG. B19 DNA was not found in any of the subjects (0%). Conclusion: The result of this study showed that none of the blood donors had detectable parvovirus B19 DNA. This means that there was a very low risk of transmission of parvovirus B19 through blood or blood derived products. It is recommended that more blood samples to be studied specially in high risk groups.
M Delfan-Beiranvand , Y Pournia , M Fazeli , Ah Tarvand , J Hosseini , M Mirzaei ,
Volume 6, Issue 1 (2-2012)
Abstract
Background and Aims: Cytomegalovirus (CMV) has worldwide distribution, and its prevalence rate depends on factors such as economic and geographical conditions. An important way of the virus transmission is via blood. Due to high prevalence of anti-CMV antibodies in blood donors and lack of data concerning its seroprevalence in the region, this study was carried out to determine the prevalence rate of anti-CMV antibodies in the blood donors of Khorramabad Blood Transfusion Center. Materials and Methods: This descriptive study was conducted on 270 healthy donors referring to Khorramabad Blood Transfusion Center. The demographic data were recorded in the questionnaires, and following the routine screening tests, the tests of anti-CMV antibodies (IgG and IgM) were performed using the Iranian Pishtaz-teb kit through the ELISA technique. The data were analyzed by the t-test and x2 test using the SPSS software. Results: Out of 270 samples, 90% were males, and 10% were females. Anti-CMV IgG antibody was positive in 148 samples (55%), and negative in 122 ones (45%). Moreover, anti-CMV IgM antibody was negative in 269 cases (99.6%), and positive in 1 case (0.4%). Conclusion: Considering the high seroprevalence of anti-CMV antibody in Khorramabad, latency of the virus inside the blood cells, and its possible transmission via blood and blood products to blood receivers particularly in immunodeficient patients including those with malignant diseases receiving chemotherapy and recipients of allograft transplants, performing screening tests on donated blood samples for CMV infection particularly in high risk cases is recommended.
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