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Showing 5 results for Hbsag
Zohreh Sharifi, Mahmood Mahmoodian Shooshtari,
Volume 2, Issue 1 (2-2008)
Abstract
Zohreh Aminzadeh, Ziba Shabani Shahrbabaki, Latif Ghachkar, Ahmad Reza Sayyadi Anari,
Volume 2, Issue 3 (12-2008)
Abstract
Mj Zahedi , S Darvish-Moghaddam , H Zareei ,
Volume 3, Issue 2 (9-2009)
Abstract
Background and Aims: Hepatitis D virus (HDV) can infect human population either as a superinfection or concurrent hepatitis B virus (HBV) infection. It is expected that presence of HDV infection is more prevalent in endemic HBV areas. Overall 5% of Iranian general populations are chronic HBV carriers. The aim of this study was to determine the seroprevalence of HDV and its clinical impact in a local area of southern Iran (Kerman province).
Methods: The study carried out during 2006-2007 on all hepatitis B surface antigens (HBsAg) positive subjects who referred to the main referral hospital (Afzalipour Academic Health Center) and subspecialty GI offices in the city of Kerman. The study included just stable chronic hepatitis B and inactive HBV carriers around the province. High risk group subjects and other concurrent hepatitis viral infections were excluded.
Results: One hundred and ninety six patients were enrolled in the study. They consist of 143 (73%) men, 53 (27%) women, with a mean age of 39.2 ± 7.1 (range 20-60) years. Twenty-one subjects (10.7%) were positive for anti HDV antibody (Ab). Male to female ratio was 6/1 in this group. All of the HDV positive cases acquired the infection as a super-infection. Elevated aminotransferases (ALT- AST) was documented in 81% of HDV positive cases and in 41% of HDV negative subjects (p=0.001).
Conclusion: HDV investigation is recommended in HBV infected patients, particularly those with elevated liver enzymes in a relatively high prevalent area as in Iran.
A Ghaziasadi , M Ziai , M Norouzi , R Malekzadeh , Sm Alavian , M Judaki , S Ghamari , A Khedive , A Namazi , Sm Jazayeri ,
Volume 5, Issue 2 (5-2011)
Abstract
Background and Aims: The aim of this study was to determine the correlation between the hepatitis B virus surface Ag (HBsAg) genotypes and variations in the clinical/serological pictures among HBsAg positive chronic patients from South Khorasan province of Iran. Methods: Twenty-five patients were enrolled in this study. The HBs Ag gene was amplified and was directly sequenced. Genotypes and nucleotide/amino acid substitutions were characterized comparing with sequences obtained from the database. Results: All strains belonged to genotype D, subgenotype D1 and subtype ayw2. Eight samples (group I) contained at least one mutation at the single amino acid level. Five out of 8 samples showed ALT levels above the normal range of which only one sample was anti-HBe positive. Group II (17 samples) did not contain any mutation, 4 were anti-HBe positive and 9 had increased ALT levels. In both groups, in anti-HBe positive patients who showed high levels of ALT, only one sample had amino acid mutations. Conversely, 7 of 20 samples with HBeAg positivity had mutations. In both groups, from a total of 18 amino acid mutations, 5 (27.5%) and 13 (72.5%) occurred in anti-HBe and HBeAg positive groups respectively. In general, there was no correlation between the occurrence of mutations and HBeAg status/ALT levels of the patients. Conclusion: The relatively small number of nucleotide/amino acid mutations might belong to either the initial phase (tolerant phase) of chronicity in our patients, regardless of being anti-HBe positive or that even in anti-HBe positive phase in Iranian genotype D-infected patients, a somehow tolerant pattern due to the host genetic factors may be responsible.
Hossein Keyvani, Fatemeh Ramezani, Seyem Mohamad Jazayeri, Seyed Hamid Reza Monavari, Farah Bokharaei-Salim, Seyed Moayed Alavian, Ghodrat Montazeri, Mehdi Norouzi, Maryam Daram, Abolfazl Khedive, Reza Malekzadeh, Mohamad Amin Pourhoseingholi, Reza Rezaee, Lars Magnius, Helen Norder,
Volume 8, Issue 2 (11-2014)
Abstract
Abstract Background: Naturally occurred hepatitis B virus (HBV) with surface mutations in a variety of chronic hepatitis B (CHB) patients who have received no vaccine or HBIG bearing substitutions in surface protein, have been reported. Objectives: Current knowledge concerning the prevalence of these naturally occurring surface antigen mutations among Iranian carriers is limited. Patients and Methods: In a retrospective cross-sectional study, 119 inactive HBV chronic carriers were enrolled. The surface gene was amplified, sequenced and subsequently aligned using international and national sequence database. Results: All strains belonged to genotype D, subgenotype D1 and subtype ayw2. In 74 (62.18%) of patients, 146 (68.8%) out of 212 amino acid mutations occurred in different immune epitopes within surface protein, of which 28 (19.17%) in B cell, 37 (25.34%) in T helper and 81 (55.47%) inside CTL epitopes. 13 (8.9%) and 15 (10.27%) of amino acid substitutions occurred outside and within the “a” determinant in Major Hydrophilic Region (MHR). While 11 (9.24%) and 77 (64.7%) patients who harbored amino acid mutations, were HBeAg and anti-HBe positive, respectively (p=0.004). 9 and 63 amino acid mutations were occurred in different HBsAg epitopes in HBeAg and anti-HBe positive patients, respectively (P=0.04). Conclusions: HBV mutants within the surface immune epitopes seem to be extremely common among chronic carriers from Tehran, especially those who are anti-HBe positive, indicating that after HBeAg seroconversion, due to the selection pressure of e antibody, the occurrence of mutation is an inevitable effect of the evolutionary process.
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