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جلد 15 شماره 1 صفحات 14-7 برگشت به فهرست نسخه ها
A Novel Genetic classification of SARS coronavirus-2 following whole nucleic acid and protein alignment of the isolated viruses
چکیده:   (450 مشاهده)
Background and aims: The end of 2019 has marked the year, which the human population encountered a novel virus; SARS-CoV-2 that causes a disease namely COVID-19. Here we focused on the genome and protein mutations and subsequently suggested a new classification of the SARS-CoV-2.
Materials and Methods: Our study showed that some extra positions in the virus genome play a key role in the SARS-CoV-2 classification. Based on the analysis of the whole genome sequences of 93 viruses.
Results: mutations were classified into nine divisions including IA-1, IA-2, IA-3, IB, II, L1, L2, L3 and S. Totally, 279 mutations were found in the SARS-CoV-2 genomes. 24 mutations lead to the amino acid frame shifting, of which 15 mutations lead to positive frame shifting in amino acids sequences.
Conclusion: Sequence alignment of these positions with that of ancestors showed no change suggesting that they might have occurred in the SARS-CoV-2 genomes to adapt itself to humans.
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نوع مطالعه: پژوهشي | موضوع مقاله: تخصصي
دریافت: 1399/9/15 | پذیرش: 1400/4/13 | انتشار: 1400/3/30
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Sanchooli A, Shahkarami M K, Thekkiniath J, Karimi Naghlani S, Kamali M, Cheraghi M et al . A Novel Genetic classification of SARS coronavirus-2 following whole nucleic acid and protein alignment of the isolated viruses. Iran J Virol. 2021; 15 (1) :7-14
URL: http://journal.isv.org.ir/article-1-416-fa.html

A Novel Genetic classification of SARS coronavirus-2 following whole nucleic acid and protein alignment of the isolated viruses. مجله ویروس شناسی ایران. 1400; 15 (1) :14-7

URL: http://journal.isv.org.ir/article-1-416-fa.html



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دوره 15، شماره 1 - ( 4-1400 ) برگشت به فهرست نسخه ها
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