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:: Volume 7, Issue 3 (9-2013) ::
Iran J Virol 2013, 7(3): 1-6 Back to browse issues page
Caspase Cleavage Motifs of Influenza Subtypes Proteins: Alternations May Switch Viral Pathogenicity
Shahla Shahsavandi , Mohammad Majid Ebrahimi , Kaveh Sadeghi
Razi Vaccine and serum Research Institute, P.O. Box 31975-148, Karaj, Iran
Abstract:   (2491 Views)

Background and Aims: The caspases are unique proteases that mediate the host cell apoptosis during viral infection. In this study, we identified the caspase cleavage motifs of H5N1 and H9N2 influenza viruses isolated during 1998-2012. Materials and Methods: Amino acid sequences of the eleven proteins encoded by the viruses as the caspase substrates downloaded from NCBI. The caspase cleavage motifs predicted at the three scanning P4P1, P4P2', and P14P10'–trained support vector machine classifier. Results: Data showed that H5N1 and H9N2 viruses were represented the same cleavage motif pattern for some of the viral proteins substrates. The HA, NP, and NS1 of H9N2 viruses were found to possess additional cleavage motifs from 2005, when an outbreak wave of H5N1 viruses was expanded through Asia. Conclusion: Moreover, the cleavage motif of PB1-F2 protein was differing in both subtypes. The results indicated that the caspase activity of PB1-F2 protein may be involve in the viral pathogenicity.

Keywords: Influenza virus, subtypes, Caspase Cleavage Motif, pathogenicity
Full-Text [PDF 72 kb]   (702 Downloads)    
Type of Study: Original article | Subject: General
Received: 2015/05/21 | Accepted: 2015/05/22 | Published: 2015/05/22
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Shahsavandi S, Ebrahimi M M, Sadeghi K. Caspase Cleavage Motifs of Influenza Subtypes Proteins: Alternations May Switch Viral Pathogenicity. Iran J Virol. 2013; 7 (3) :1-6
URL: http://journal.isv.org.ir/article-1-129-en.html


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