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:: Volume 9, Issue 4 (8-2015) ::
Iran J Virol 2015, 9(4): 1-8 Back to browse issues page
Serum and Urine Level of IP-10 in Patients with HCV infection Based on Clinical and Virological Markers
Zahra Moallemi, Jamshid Ayatollahi , Masoud Doosti
Associate Professor, Infectious and Tropical Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:   (1662 Views)

Abstract

Background and Aims: IP-10 molecule is a new biomarker to predict response to treatment in chronic HCV infection. Also urine IP-10 has been suggested as a biomarker in other infections. But already, it has low data in urine as well as serum level of IP-10 for HCV infection. The aim of this study was to assess urine and serum level of IP-10 in patients with type 1 and 3a HCV infection.

Materials and Methods: In this case-control study, 105 patients with HCV infection were involved in three 35 people groups. Blood and urine sample of all patients was collected to determine IP-10 level. Finally, data analysis was reported using SPSS, mean statistics analysis and T test.

Results: The age mean was 41.6±11.2 ranging 21-68. Urine and serum level of IP-10 in patient group was significantly higher than control (p=0.001). Serum level of IP-10 based on HCV genotype was higher significantly in genotype 1a than 3a (p=0.001) but there was no significant difference of urine IP-10 level between genotypes 1a and 3a.

Conclusions: The results show IP-10 is a proper marker to determine the prognosis of fibrosis and progress liver inflammation and on the other hand, the prediction of response to treatment differs in various genotypes of HCV infection.

Keywords: Hepatitis C, IP-10, serum and urine, genotype 3a and 1a
Full-Text [PDF 534 kb]   (628 Downloads)    
Type of Study: Original article | Subject: General
Received: 2016/08/30 | Accepted: 2016/09/9 | Published: 2016/09/9
  • IP-10 is a proper marker to determine the prognosis of fibrosis and progress liver inflammation.
  • The prediction of response to treatment differs in various genotypes of HCV infection.


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Moallemi Z, Ayatollahi J, Doosti M. Serum and Urine Level of IP-10 in Patients with HCV infection Based on Clinical and Virological Markers. Iran J Virol. 2015; 9 (4) :1-8
URL: http://journal.isv.org.ir/article-1-219-en.html


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