[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 3, Issue 1 (6-2009) ::
Iran J Virol 2009, 3(1): 25-28 Back to browse issues page
Investigation of the Relationship between the Residual Moisture and Thermal Stability of Lyophilized MMR Vaccine
MK Shahkarami , M Taqavian , A Shafyi , B Alirezaie , F Esna-ashari , S Soleimani , R Shahbazi
Human Viral Vaccines Department, Razi Vaccine & Serum Research Institute, Iran
Abstract:   (2442 Views)

Background and Aims: The safe, potent and effective live vaccines against Measles, Mumps and Rubella as important childhood diseases have been available for several decades. Several factors can affect the thermal stability of lyophilized vaccine.

Methods: In this study, the effect of residual moisture on thermal stability of 61 batches of MMR vaccine was investigated using an accelerated method that has been recommended by World Health Organization (WHO).

Results: Our results suggest that the best thermal stability for the lyophilized MMR vaccine is in a range of 1.51 to 2.00% of residual moisture with the minimum decrease in the all three components of the vaccines.

Conclusion: It is suggested that the lyophilizators of MMR vaccine production lines should be programmed in a manner that the best range of residual moisture achieves.

Keywords: Thermostability, MMR vaccine, Residual moisture
Full-Text [PDF 129 kb]   (991 Downloads)    
Type of Study: Original article | Subject: General
Received: 2014/09/28 | Accepted: 2014/09/28 | Published: 2014/09/28
Add your comments about this article
Your username or Email:

CAPTCHA code



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Shahkarami M, Taqavian M, Shafyi A, Alirezaie B, Esna-ashari F, Soleimani S et al . Investigation of the Relationship between the Residual Moisture and Thermal Stability of Lyophilized MMR Vaccine. Iran J Virol. 2009; 3 (1) :25-28
URL: http://journal.isv.org.ir/article-1-25-en.html


Volume 3, Issue 1 (6-2009) Back to browse issues page
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3781