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:: Volume 9, Issue 4 (8-2015) ::
Iran J Virol 2015, 9(4): 29-34 Back to browse issues page
Sero-prevalence of Herpes Simplex and Epstein Barr Viruses in HIV positive patients in Tehran
Atefeh Bahavar, Seyed Hamid Reza Monavari, Hossein Keyvani, Maryam Esghaei, Saied Ghorbani, Angila Ataei-Pirkooh
Department of Virology, Iran University of Medical Sciences, Tehran, Islamic Republic of Iran
Abstract:   (3218 Views)

Abstract

Background and Aims: The burden of HIV infection and disease continues to be a major global public health concern all over the world. This study was conducted to measure IgG antibody against EBV viral capsid antigen (EBV-VCA IgG), Herpes Simplex Type1, and 2 to determine the seroprevalence of this infection in HIV-positive population.

Materials and Methods: A Cross-sectional study between March and August 2016 was conducted in keyvan virology laboratory enrolling 84 HIV-positive patients with different age and sexes. Enzyme-linked immunosorbent assay (ELISA) was used for determination of IgG antibody against Herpes Simplex Type1, Type 2 viruses, EBV and HIV viral load detected in plasma by Real time-PCR in obtained samples from HIV-positive patients.

Results: The overall seroprevalence was 66.7% for anti-HSV-1 IgG, 14.3% for anti-HSV-2 IgG, and 94% for anti-EBV IgG. There was no significant difference between the sex groups for HSV-1 and -2, EBV and HIV load and their IgG level. This study also showed a correlation between the age, and the antibody titers only for HSV-1 and -2 with P=0.030 and P= 0.024, respectively.

Conclusions: In our study, the seroprevalence of EBV and HSV-1 IgG were higher in HIV-positive patients. It can be derived that HSV-2 virus is not major coinfection in Iran, thus requires less attention than others, but annually monitoring needs for proper health care programs.

Keywords: Keywords: HIV, EBV, HSV-1, HSV-2, Sero-prevalence
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Type of Study: Original article | Subject: General
Received: 2016/12/26 | Accepted: 2017/02/25 | Published: 2017/02/25
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Bahavar A, Monavari S H R, Keyvani H, Esghaei M, Ghorbani S, Ataei-Pirkooh A. Sero-prevalence of Herpes Simplex and Epstein Barr Viruses in HIV positive patients in Tehran. Iran J Virol. 2015; 9 (4) :29-34
URL: http://journal.isv.org.ir/article-1-258-en.html


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